"The Way She Moves" featuring Akon was selected as the lead single from the album. The song was released to radio stations on June 12, 2007 and released as a digital download on April 9, 2008. "Zun Da Da" served as the second single and was released to radio stations on July 20, 2007 and released as a digital download on April 9, 2008, as well.The Perfect Melody received a nomination for a Lo Nuestro Award for Urban Album of the Year.
Zion first became known in the duo Zion & Lennox. As a duo, they released one studio album, Motivando a la Yal (2004) and appeared on various compilation albums before then such as Luny Tunes'Mas Flow (2003). Motivando a la Yal peaked at number thirty-two and number thirteen on the Billboard Latin Albums and Billboard Latin Pop Albums, respectively. The special edition re-release performed better, reaching number ten on the Billboard Latin Albums chart. The album was well received by critics, with Evan Gutierrez of Allmusic calling it a "landmark album" and "one of the albums that artists will refer to in years to come as one of the records that shaped reggaeton and its future". Zion began working on The Perfect Melody in October 2007. Originally, the album was to be a compilation album of various artist, though after "bad experiences with new talent", Zion decided to work the project alone.