Thomas Kilduff

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Thomas Kilduff
Alma mater University of Florida
Stanford University
Known for Discovery of hypocretin
Awards 2009 AAAS Fellow
Scientific career
Fields Neuroscience, particularly the neurobiology of sleep and wakefulness
Institutions Ames Research Center
Stanford University School of Medicine
SRI International
Academic advisors Wilse B. Webb, Craig Heller, Bill A. Williams, William C. Dement

Thomas S. Kilduff is an American neuroscientist and the director of SRI International's Center for Neuroscience. He specializes in neurobiology related to sleep and wakefulness, and was involved in the discovery of hypocretin (also known as orexin),[1][2] a neuropeptide system that is highly involved in wakefulness regulation.[3][4][5]

His group at SRI International also discovered an unusual neuronal population in the cerebral cortex that is activated during sleep.[6][7][8]

He is also a consulting professor at the Stanford University School of Medicine's Department of Psychiatry and Behavioral Sciences.[3]


Kilduff obtained a B.S. from the University of Florida and earned an M.S. and a Ph.D. in biological sciences from Stanford University, where he was also awarded fellowships from the Danforth Foundation, the Grass Foundation, and the National Science Foundation.[9]


Kilduff was a senior research scientist at Stanford University's Center for Sleep and Circadian Neurobiology.[9] He was also a visiting scientist in the Scripps Research Institute's Department of Molecular Biology, a visiting professor at the University of Perugia's Istituto di Biologia Cellulare, and a National Academy of Sciences National Research Council research associate at NASA's Ames Research Center.[10]

In 1999, Kilduff joined SRI International as part of a new molecular neurobiology group, where he subsequently founded the Sleep Neurobiology Program before becoming director of the Center for Neuroscience.[10][11]


Kilduff's early research focused on the neural control of mammalian hibernation[12][13][14] and circadian rhythms.[15] [16][17]

Kilduff and scientists at the Scripps Research Institute co-discovered hypocretin (also known as orexin), a neuropeptide system that is involved in the control of wakefulness.[11] Subsequent research established that the hypocretin neurons degenerate in the sleep disorder narcolepsy and is the likely cause of this disorder.[18][19]

Awards and memberships[edit]

He was named a Fellow Member of the American Association for the Advancement of Science in the December 18, 2009 issue of Science.[9][20] He was named an SRI Fellow in 2010 [3] and a Distinguished Scientist by the SRS in 2017.[21]

He is a member of the Society for Neuroscience has served on the boards of the Associated Professional Sleep Societies, the Sleep Research Society, and was a Founding Member of the Sleep Research Society Foundation.[11][22]

See also[edit]


  1. ^ de Lecea, L.; Kilduff, T.S.; Peyron, C.; Gao, X.-B.; Foye, P.E.; Danielson, P.E.; Fukuhara, C.; Battenberg, E.L.F.; Gautvik, V.T.; Bartlett II, F.S.; et al. (1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity". Proceedings of the National Academy of Sciences USA. 95 (1, number 1): 322–327. doi:10.1073/pnas.95.1.322. PMC 18213Freely accessible. PMID 9419374. 
  2. ^ Sakurai, T.; Amemiya, A.; Ishii, M.; Matsuzaki, I.; Chemelli, R.M.; Tanaka, H.; Williams, S.C.; Richardson, J.A.; Kozlowski, G.P.; Wilson, S.; et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior". Cell. 92 (4, number 4): 573–585. doi:10.1016/S0092-8674(00)80949-6. PMID 9491897. 
  3. ^ a b c "Our People: Thomas Kilduff". SRI International. Retrieved 2013-04-28. 
  4. ^ Thomas S. Kilduff; Ed S. Lein; Horacio de la Iglesia; Takeshi Sakurai; Ying-hui Fu & Paul Shaw (2008-11-12). "New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology". The Journal of Neuroscience. 28 (46): 11814–11818. doi:10.1523/jneurosci.3768-08.2008. PMC 2628168Freely accessible. PMID 19005045. 
  5. ^ Kilduff, T.S. & Peyron, C. (2000). "The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders". Trends in Neurosciences. 23 (8, number 8): 359–365. doi:10.1016/s0166-2236(00)01594-0. PMID 10906799. 
  6. ^ "SRI International Research Team Identifies Rare Sleep-Activated Neurons in the Cerebral Cortex". SRI International. 2008-07-21. Retrieved 2013-06-15. 
  7. ^ Gerashchenko, D.; Wisor, J.P.; Burns, D.; Reh, R.K.; Shiromani, P.J.; Sakurai, T.; de la Iglesia, H.O. & Kilduff, T.S (2008). "Identification of a population of sleep-active cerebral cortex neurons". Proceedings of the National Academy of Sciences USA. 105 (29): 10227–10232. doi:10.1073/pnas.0803125105. PMC 2481371Freely accessible. 
  8. ^ Kilduff, T.S.; Cauli, B. & Gerashchenko, D. (2011). "Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?". Trends in Neurosciences. 34 (1, number 1): 10–19. doi:10.1016/j.tins.2010.09.005. PMC 3014438Freely accessible. PMID 21030095. 
  9. ^ a b c "SRI International Researcher Named American Association for the Advancement of Science (AAAS) Fellow". SRI International. 2010-01-20. Retrieved 2013-04-28. 
  10. ^ a b "Stanford Scientist Thomas Kilduff Joins SRI International as Senior Program Director of Newly Formed Molecular Neurology Group". SRI International. 1999-01-25. Archived from the original on 2000-07-09. Retrieved 2013-04-28. 
  11. ^ a b c "Candidate: President Elect: Thomas Kilduff, PhD" (PDF). Sleep Research Society. Retrieved 2013-04-2013.  Check date values in: |accessdate= (help)
  12. ^ Kilduff TS, Bowersox SS, Faull KF, et al. (1987). "Modulation of activity of the striatal dopaminergic system during the hibernation cycle". Neuroscience (7): 2732–2736. 
  13. ^ Kilduff TS, Miller JD, Radeke CM, Sharp FR, Heller HC (1990). "14C-2-deoxyglucose uptake in the ground squirrel brain during entrance to and arousal from hibernation". Neuroscience (10): 2463–2475. 
  14. ^ Kilduff TS, Sharp FR, Heller HC (1982). "[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation". Neuroscience (2): 143–157. 
  15. ^ Kilduff TS, Vugrinic C, Lee SL, et al. (1998). "Characterization of the circadian system of NGFI-A and NGFI-A/NGFI-B deficient mice". Journal of Biological Rhythms (13): 347–357. 
  16. ^ Sutin EL, Dement WC, Heller HC, Kilduff TS (1993). "Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats". Neurobiology of Aging (14): 441–446. 
  17. ^ Sutin EL, Kilduff TS (1992). "Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus". Molecular Brain Research (15): 281–290. 
  18. ^ Peyron, C.; Faraco, J.; Rogers, W.; Ripley, B.; Overeem, S.; Charnay, Y.; Nevsimalova, S.; Aldrich, M.; Reynolds, D.; Albin, R.; et al. (2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains". Nature Medicine. 6 (9, number 9): 991–997. doi:10.1038/79690. PMID 10973318. 
  19. ^ Thannickal, T.; Moore, R.; Y., Nienhuis; R., Ramanathan; L., Gulyani; S., Aldrich; M., Cornford, M. & Siegel, J.M. (2000). "Reduced number of hypocretin neurons in human narcolepsy". Neuron. 27 (3, number 3): 469–474. doi:10.1016/s0896-6273(00)00058-1. PMID 11055430. 
  20. ^ "Fellows". American Association for the Advancement of Science. Retrieved 2013-04-28. 
  21. ^ "Distinguished Scientist Award". Sleep Research Society. 
  22. ^ "Thomas Kilduff". Frontiers. Retrieved 2013-07-28.