Tolypocladium inflatum

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Tolypocladium inflatum
Scientific classification
Kingdom: Fungi
Phylum: Ascomycota
Class: Sordariomycetes
Subclass: Sordariomycetidae
Order: Hypocreales
Family: Ophiocordycipitaceae
Genus: Tolypocladium
Species: T. inflatum
Binomial name
Tolypocladium inflatum
W. Gams

Tolypocladium inflatum is an asexual ascomycete fungus originally isolated from a Norwegian soil sample that, in certain conditions, produces ciclosporin.

The fungus from which ciclosporin was first isolated was originally misidentified as Trichoderma polysporum.[1] Gams later showed the fungus belonged in a new genus of molds, Tolypocladium, and he coined the name Tolypocladium inflatum for the ciclosporin fungus.[2] In 1983, Bissett found T. inflatum was the same as Pachybasium niveum, and since the older name would have priority under the rules of botanical nomenclature, Bissett made the combination Tolypocladium niveum.[3] However, because of the economic importance of the fungus in the pharmaceutical industry, the name T. inflatum was later formally conserved to avoid confusion, so today the correct name of the mold that produces ciclosporin is Tolypocladium inflatum.

In 1996, Kathie Hodge and colleagues determined the mold T. inflatum is the asexual state of Elaphocordyceps subsessilis (formerly Cordyceps subsessilis).[4] Whereas the sexual Elaphocordyceps subsessilis state is a pathogen of beetles, the asexual T. inflatum state is widely distributed in soils.


  1. ^ Dreyfuss M, Härri E, Hofmann H, Kobel H, Pache W, Tscherter H. (1976). "Cyclosporin A and C: new metabolites from Trichoderma polysporum (Link ex Pers.) Rifai". European Journal of Applied Microbiology 3: 125–133.
  2. ^ Gams W. (1971). "Tolypocladium, eine Hyphomycetengattung mit geschwollenen Phialiden". Persoonia 6: 185–191.
  3. ^ Bissett J. (1983). "Notes on Tolypocladium and related genera". Canadian Journal of Botany 61: 1311–1329.
  4. ^ Hodge KT, Krasnoff SB, Humber RA. (1996). "Tolypocladium inflatum is the anamorph of Cordyceps subsessilis". Mycologia 88: 715–719.