Cherones grew up in Tuscaloosa, Alabama, where his father operated a radio and TV repair shop. His grandfather was a Greek immigrant. From 1961 to 1965, he was a lieutenant in the United States Navy.
Cherones began working in educational television while a student at the University of Alabama and later produced and directed programs for WQED in Pittsburgh. His first work after moving to Hollywood in 1975 was as a production manager for General Hospital.
Cherones began as a television director on My Sister Sam in the 1980s. In the 1990s, he became noted for directing and producing Seinfeld (81 episodes) and NewsRadio (56 episodes). His work on Seinfeld won him high praise as well as an Emmy, a DGA Award and a Golden Globe Award. In 2003, he was inducted into the Alabama Stage and Screen Hall of Fame.
For several years in the early 2000s, Cherones taught a film production course at the University of Alabama, where he had earned a Master's degree in 1976.
- "Four Distinguished Communication Leaders to be Inducted into C&IS Hall of Fame at UA". The University of Alabama. October 1, 2001. Retrieved May 13, 2016.
- "The Alabama Stage and Screen Hall of Fame". Theatretusc.com. Retrieved 2014-07-20.
- "Port Hole Publications". Port Hole Publications. Retrieved 2014-07-20.
- "HOME". The Hardly Boys. Retrieved 2014-07-20.