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Trophinin

From Wikipedia, the free encyclopedia

TRO
Identifiers
AliasesTRO, MAGE-d3, MAGED3, trophinin
External IDsOMIM: 300132; MGI: 1928994; HomoloGene: 75113; GeneCards: TRO; OMA:TRO - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)

n/a

Location (UCSC)Chr X: 54.92 – 54.93 MbChr X: 149.43 – 149.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trophinin is a protein that in humans is encoded by the TRO gene.[5][6][7]

This gene encodes a membrane protein that mediates apical cell adhesion between trophoblastic cells and luminal epithelial cells of the endometrium and is implicated in the initial attachment during the process of embryo implantation. This gene is related to the MAGED gene family by sequence similarity and chromosome location. Multiple alternatively spliced transcript variants have been found for this gene; however, the full-length nature of some variants has not been defined.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067445Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025272Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pack SD, Tanigami A, Ledbetter DH, Sato T, Fukuda MN (Apr 1998). "Assignment of trophoblast/endometrial epithelium cell adhesion molecule trophinin gene TRO to human chromosome bands Xp11.22→p11.21 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 123–4. doi:10.1159/000134698. PMID 9533028.
  6. ^ Chomez P, De Backer O, Bertrand M, De Plaen E, Boon T, Lucas S (Jul 2001). "An overview of the MAGE gene family with the identification of all human members of the family". Cancer Res. 61 (14): 5544–51. PMID 11454705.
  7. ^ a b "Entrez Gene: TRO trophinin".

Further reading

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