Turritopsis dohrnii

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Immortal jellyfish
Turritopsis dohrnii.jpg
Turritopsis dohrnii medusa
Scientific classification e
Kingdom: Animalia
Phylum: Cnidaria
Class: Hydrozoa
Order: Anthoathecata
Family: Oceaniidae
Genus: Turritopsis
Species: T. dohrnii
Binomial name
Turritopsis dohrnii
(Weismann, 1883)[1]

Turritopsis dohrnii, the immortal jellyfish, is a species of small, biologically immortal jellyfish[2][3] found in the Mediterranean Sea and in the waters of Japan. It is one of the few known cases of animals capable of reverting completely to a sexually immature, colonial stage after having reached sexual maturity as a solitary individual. Others include the jellyfish Laodicea undulata[4] and Aurelia sp.1.[5]

Like most other hydrozoans, T. dohrnii begin their life as free-swimming tiny larvae known as planula. As a planula settles down, it gives rise to a colony of polyps that are attached to the sea-floor. All the polyps and jellyfish arising from a single planula are genetically identical clones. The polyps form into an extensively branched form, which is not commonly seen in most jellyfish. Jellyfish, also known as medusae, then bud off these polyps and continue their life in a free-swimming form, eventually becoming sexually mature. When sexually mature they have been known to prey on other jellyfish species at a rapid pace. If a T. dohrnii jellyfish is exposed to environmental stress or physical assault, or is sick or old, it can revert to the polyp stage, forming a new polyp colony.[6] It does this through the cell development process of transdifferentiation, which alters the differentiated state of the cells and transforms them into new types of cells.

Theoretically, this process can go on indefinitely, effectively rendering the jellyfish biologically immortal,[3][7] although in practice individuals can still die. In nature, most Turritopsis are likely to succumb to predation or disease in the medusa stage, without reverting to the polyp form.[8]

The capability of biological immortality with no maximum lifespan makes T. dohrnii an important target of basic biological, aging and pharmaceutical research.[9][10]

The "immortal jellyfish" was formerly classified as T. nutricula.[11]

Description[edit]

The medusa of Turritopsis dohrnii is bell-shaped, with a maximum diameter of about 4.5 millimetres (0.18 in) and is about as tall as it is wide.[12][13] The jelly in the walls of the bell is uniformly thin, except for some thickening at the apex. The relatively large stomach is bright red and has a cruciform shape in cross section. Young specimens 1 mm in diameter have only eight tentacles evenly spaced out along the edge,[14] whereas adult specimens have 80–90 tentacles. The medusa (jellyfish) is free-living in the plankton. Dense nerve net cells are also present in the epidermis in the cap. They form a large ring-like structure above the radial cannal which is commonly presented in cnidarians.[15]

Turritopsis dohrnii also has a bottom-living polyp form, or hydroid, which consists of stolons that run along the substrate, and upright branches with feeding polyps that can produce medusa buds.[16] These polyps develop over a few days into tiny 1 mm medusae, which are liberated and swim free from the parent hydroid colony.

Images of both the medusa and polyp of the closely related species Turritopsis rubra from New Zealand can be found online.[17] Until a recent genetic study, it was thought that Turritopsis rubra and Turritopsis nutricula were the same.[11] It is not known whether or not T. rubra medusae can also transform back into polyps.

Distribution and invasion[edit]

Turritopsis is believed to have originated in the Pacific but has spread all over the world through trans-Arctic migrations, and has speciated into several populations that are easy to distinguish morphologically, but whose species distinctions have recently been verified by a study and comparison of mitochondrial ribosomal gene sequences.[11][18] Turritopsis are found in temperate to tropical regions in all of the world's oceans.[13] Turritopsis is believed to be spreading across the world through ballast water discharge.[13] Unlike other species invasions which caused serious economic and ecological consequences, T. dohrnii’s invasion around the world was unnoticed due to their tiny size and innocuity.[19] "We are looking at a worldwide silent invasion", said Smithsonian Tropical Marine Institute scientist Dr. Maria Miglietta.[18]

Life cycle[edit]

The eggs develop in gonads of female medusae, which are located in the walls of the manubrium (stomach). Mature eggs are presumably spawned and fertilized in the sea by sperm produced and released by male medusae, as is the case for most hydromedusae, although the related species Turritopsis rubra seems to retain fertilized eggs until the planula stage.[17] Fertilized eggs develop into planula larvae, which settle onto the sea-floor (or even the rich marine communities that live on floating docks), and develop into polyp colonies (hydroids). The hydroids bud new jellyfishes, which are released at about one millimetre in size and then grow and feed in the plankton, becoming sexually mature after a few weeks (the exact duration depends on the ocean temperature; at 20 °C (68 °F) it is 25 to 30 days and at 22 °C (72 °F) it is 18 to 22 days).[3] Medusae of T. dohrnii are able to survive between 14 °C and 25 °C.[3][14]

Biological immortality[edit]

Most jellyfish species have a relatively fixed life-span, which varies by species from hours to many months (long-lived mature jellyfish spawn every day or night; the time is also fairly fixed and species-specific).[20] The medusa of Turritopsis dohrnii is the only form known to have developed the ability to return to a polyp state, by a specific transformation process that requires the presence of certain cell types (tissue from both the jellyfish bell surface and the circulatory canal system).[21]

Careful laboratory experiments have revealed that all stages of the medusae, from newly released to fully mature individuals, can transform back into polyps under the conditions of starvation, sudden temperature change, reduction of salinity and artificial damage of the bell with forceps or scissor.[3] The transforming medusa is characterized first by deterioration of the bell, mesoglea and tentacles. All immature medusa (with 12 tentacles at most) then turned into a cyst-like stage and then transformed into stolons and polyps. However, about 20%-40% of mature medusa went into stolons and polyps stage without passing cyst-like stage. Polyps were formed after 2 days since stolons had developed and fed on food. Polyps further multiply by growing additional stolons, branches and then polyps, to form colonial hydroids. In the experiment, they would eventually transform into stolons and polyps and begin their lives once again even without suffering from environment changes or injury.[3] Diagram of the transformation procedure can be found at the further reading.

This ability to reverse the biotic cycle (in response to adverse conditions) is unique in the animal kingdom, and allows the jellyfish to bypass death, rendering Turritopsis dohrnii potentially biologically immortal. The process has not been observed in their natural habitat, in part because the process is quite rapid, and because field observations at the right moment are unlikely.[3] Regardless, most individual medusae are likely to fall victim to the general hazards of life as plankton, including being eaten by predators or succumbing to disease.

The species' cell development method of transdifferentiation has inspired scientists to find a way to make stem cells using this process for renewing damaged or dead tissue in humans.[10]

Genomic analysis[edit]

Genomic analyses such as sequence analysis on mRNA or mitochondria DNA have been employed to investigate its lifecycle. mRNA analysis of each life stage showed that a stage-specific gene in the medusae stage is expressed tenfold more than in other stages. This gene is relative to a Wnt signal that can induce a regeneration process upon injury.[22][23]

Analysis of nucleotide sequence homologs and protein homologs identified Nemopsis bachei as the species' closest relative. None of the closely related species show biological immortality.[24]

Culturing[edit]

Keeping T. dohrnii in captivity is quite difficult. Currently only one scientist, Shin Kubota from Kyoto University, has managed to sustain a group of these jellyfish for a prolonged period of time. The plankton must be inspected daily to ensure that they have properly digested the Artemia cysts they are being fed.[6] Kubota reported that during a two-year period, his colony rebirthed itself 11 times.[25] Kubota regularly appears on Japanese television to talk about his immortal jellyfish and has recorded several songs about them.[6]

In popular culture[edit]

  • The Blacklist season 2 episode 17 "The Longevity Initiative" – a billionaire tech mogul whose fascination with immortality led him to develop and fund a research team for just that purpose. Leading the research is a scientist who has been injecting the cells of T. dohrnii into humans in order to hopefully force their cells to regenerate.[26]
  • Zoo season 2 episode 6 "Sex, Lies and Jellyfish" – The team searches for immortal jellyfish to find a cure for animal mutations.[27]
  • Wild Kratts Videos "Meeting the Immortal Jellyfish" – During the rescue of the Bowhead whale from Zach, Martin and Chris are thrown from the Tortuga, ending up in the Sea of Japan with a group of jellyfish. But these jellyfish are different. They're called the Immortal jellyfish and can live forever. With the help of Aviva, Martin and Chris activate with Immortal jellyfish powers and soon discover the highs and lows of living forever.[28]
  • Octonauts season 3 episode 17 "Octonauts and the Immortal Jellyfish" – The Octonauts encounter an immortal jellyfish which reverts back into a "baby jellyfish" and then matures into an adult again.
  • The design and abilities of the Vocaloid LUMi (ルミ) draw inspiration from T. dohrnii. [29][30]
  • Progressive post-metal band The Ocean wrote the song 'Turrtopsis Dohrnii,' inspired by the jellyfish.[31]

See also[edit]

References[edit]

  1. ^ WoRMS (2012). Schuchert P, ed. "Turritopsis dorhnii (Weissmann, 1883)". World Hydrozoa database. World Register of Marine Species. Retrieved November 29, 2012. 
  2. ^ Bavestrello, Giorgio; Christian Sommer; Michele Sarà (1992). "Bi-directional conversion in Turritopsis nutricula (Hydrozoa)". Scientia Marina. 56 (2–3): 137–140. 
  3. ^ a b c d e f g Piraino, Stefano; F. Boero; B. Aeschbach; V. Schmid (1996). "Reversing the life cycle: medusae transforming into polyps and cell transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)". Biological Bulletin. Biological Bulletin, vol. 190, no. 3. 190 (3): 302–312. doi:10.2307/1543022. JSTOR 1543022. 
  4. ^ De Vito; et al. (2006). "Evidence of reverse development in Leptomedusae (Cnidaria, Hydrozoa): the case of Laodicea undulata (Forbes and Goodsir 1851)". Marine Biology. 149 (2): 339–346. doi:10.1007/s00227-005-0182-3. Retrieved 2015-12-31. 
  5. ^ He; et al. (2015-12-21). "Life Cycle Reversal in Aurelia sp.1 (Cnidaria, Scyphozoa)". PLoS ONE. 10 (12): e0145314. doi:10.1371/journal.pone.0145314. PMC 4687044Freely accessible. PMID 26690755. Retrieved 2015-12-31. 
  6. ^ a b c Rich, Nathaniel (November 28, 2012). "Can a jellyfish unlock the secret of immortality?". The New York Times Magazine. Retrieved October 22, 2017. 
  7. ^ Gilbert, Scott F. (2006). "Cheating Death: The Immortal Life Cycle of Turritopsis". Retrieved 2009-03-22. 
  8. ^ Ker Than (January 29, 2009). ""Immortal" Jellyfish Swarm World's Oceans". National Geographic News. Retrieved 2010-06-16. 
  9. ^ (PDF). doi:10.7537/marsscj050414.07 http://www.sciencepub.net/stem/stem0504/007_A00288stem050414_49_53.pdf.  Missing or empty |title= (help)
  10. ^ a b Dimberu, Peniel M. "Immortal Jellyfish Provides Clues for Regenerative Medicine". Singularity Hub. Retrieved 26 October 2011. 
  11. ^ a b c Miglietta, M. P.; S. Piraino; S. Kubota; P. Schuchert (November 2006). "Species in the genus Turritopsis (Cnidaria, Hydrozoa): a molecular evaluation". Journal of Zoological Systematics and Evolutionary Research (published February 2007). 45 (1): 11–19. doi:10.1111/j.1439-0469.2006.00379.x. 
  12. ^ Kramp, P. L. (1961). "Synopsis of the medusae of the world". Journal of the Marine Biological Association of the United Kingdom. 40: 1–469. doi:10.1017/s0025315400007347. 
  13. ^ a b c Mintowt-Czyz, Lech (26 January 2009). "Turritopsis nutricula: the world's only 'immortal' creature". Times Online. Archived from the original on February 3, 2009. Retrieved 2009-03-22. 
  14. ^ a b Martell, L.; Piraino, S.; Gravili, C.; Boero, F. (2016-07-02). "Life cycle, morphology and medusa ontogenesis of Turritopsis dohrnii (Cnidaria: Hydrozoa)". Italian Journal of Zoology. 83 (3): 390–399. doi:10.1080/11250003.2016.1203034. ISSN 1125-0003. 
  15. ^ Koizumi, Osamu; Hamada, Shun; Minobe, Sumiko; Hamaguchi-Hamada, Kayoko; Kurumata-Shigeto, Mami; Nakamura, Masaru; Namikawa, Hiroshi. "The nerve ring in cnidarians: its presence and structure in hydrozoan medusae". Zoology. 118 (2): 79–88. doi:10.1016/j.zool.2014.10.001. 
  16. ^ Fraser, C. McLean (1937). Hydroids of the Pacific Coast of Canada and the United States. University of Toronto Press. pp. 201 plus 44 plates. 
  17. ^ a b Schuchert, Peter. "Turritopsis rubra". Archived from the original on September 12, 2009. Retrieved 23 January 2010. 
  18. ^ a b "'Immortal' jellyfish swarming across the world". Telegraph Media Group. January 27, 2009. Retrieved 2010-06-16. 
  19. ^ Govindarajan, Annette F.; Carman, Mary R. (2016-02-01). "Possible cryptic invasion of the Western Pacific toxic population of the hydromedusa Gonionemus vertens (Cnidaria: Hydrozoa) in the Northwestern Atlantic Ocean". Biological Invasions. 18 (2): 463–469. doi:10.1007/s10530-015-1019-8. ISSN 1387-3547. 
  20. ^ Mills, C. E. (1983). "Vertical migration and diel activity patterns of hydromedusae: studies in a large tank". Journal of Plankton Research. 5 (5): 619–635. doi:10.1093/plankt/5.5.619. 
  21. ^ Mihai, Andrei (December 5, 2008). "Meet the world's only immortal animal". ZME Science. Retrieved January 10, 2015. 
  22. ^ Logan, Catriona Y.; Nusse, Roel (2004-10-08). "The wnt signaling pathway in development and disease". Annual Review of Cell and Developmental Biology. 20 (1): 781–810. doi:10.1146/annurev.cellbio.20.010403.113126. ISSN 1081-0706. 
  23. ^ Hasegawa, Yoshinori; Watanabe, Takashi; Takazawa, Masaki; Ohara, Osamu; Kubota, Shin (2016-08-01). "De Novo Assembly of the Transcriptome of Turritopsis, a Jellyfish that Repeatedly Rejuvenates". Zoological Science. 33 (4): 366–371. doi:10.2108/zs150186. ISSN 0289-0003. 
  24. ^ Devarapalli, Pratap; Science, Department of Genomic; Kerala, Central University of; Campus, Riverside Transit; Science, Opp: Nehru College of Arts and; 17, NH; Padanakkad; Nileshwer; Kasaragod. "The conserved mitochondrial gene distribution in relatives of Turritopsis nutricula, an immortal jellyfish". Bioinformation. 10 (9): 586–591. doi:10.6026/97320630010586. PMC 4209368Freely accessible. 
  25. ^ S Kubota (2011). "Repeating rejuvenation in Turritopsis, an immortal hydrozoan (Cnidaria, Hydrozoa)" (PDF). Biogeography. 13: 101–103. ISSN 1345-0662. 
  26. ^ Walker, Jodi. "'The Longevity Initiative'". Entertainment Weekly. Entertainment Weekly Inc. Retrieved 3 June 2015. 
  27. ^ Walker, Jodi (2016-07-27). "Zoo recap: Sex, Lies and Jellyfish". EW.com. Retrieved 2016-12-03. 
  28. ^ "Meeting the Immortal Jellyfish. Wild Kratts Videos. PBS KIDS". 2016-04-28. Retrieved 2017-06-24. 
  29. ^ Apps, Amino. "LUMi Interview 1 Reveals LUMi's Design!". Vocaloid | aminoapps.com. Retrieved 2017-07-24. 
  30. ^ "キャラクターデザイン 深山フギン|INTERVIEW|ヴァーチャルアーティストエージェンシーAVA". ヴァーチャルアーティストエージェンシーAVA (in Japanese). Retrieved 2017-07-24. 
  31. ^ "Hear the Ocean's Sprawling New Jellyfish-Inspired Rager". 18 September 2017. 

Further reading[edit]

External links[edit]