Tweety family member 2

TTYH2
Identifiers
Aliases	TTYH2, C17orf29, Tweety family member 2
External IDs	OMIM: 608855; MGI: 2157091; HomoloGene: 41882; GeneCards: TTYH2; OMA:TTYH2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,262,020 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	114,611,803 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; external globus pallidus; ; corpus callosum; ; subthalamic nucleus; ; pars reticulata; ; Medulla Oblongata; ; ventral tegmental area; ; pars compacta; ; Pons; ; superior vestibular nucleus;
	Top expressed in
	lumbar subsegment of spinal cord; ; left lobe of liver; ; internal carotid artery; ; external carotid artery; ; blastocyst; ; intestinal villus; ; motor neuron; ; duodenum; ; jejunum; ; pineal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; chloride channel activity; intracellular calcium activated chloride channel activity; volume-sensitive chloride channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; chloride channel complex;
Biological process	chloride transport; chloride transmembrane transport; ion transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	94015
	117160
	ENSG00000141540
	ENSMUSG00000034714
	Q9BSA4
	Q3TH73
	NM_032646; NM_052869; NM_001330453
	NM_053273
	NP_001317382; NP_116035; NP_443101
	NP_444503
	Wikidata
View/Edit Human	View/Edit Mouse

Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene. ^[5]

Function

This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141540 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034714 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tweety family member 2". Retrieved 2014-09-11.

Bisson, N.; James, D. A.; Ivosev, G.; Tate, S. A.; Bonner, R.; Taylor, L.; Pawson, T. (2011). "Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor". Nature Biotechnology. 29 (7): 653–658. doi:10.1038/nbt.1905. PMID 21706016.
Ibarrola, N; Molina, H; Iwahori, A; Pandey, A (2004). "A novel proteomic approach for specific identification of tyrosine kinase substrates using 13Ctyrosine". Journal of Biological Chemistry. 279 (16): 15805–13. doi:10.1074/jbc.M311714200. PMID 14739304.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Rae, F. K.; Hooper, J. D.; Eyre, H. J.; Sutherland, G. R.; Nicol, D. L.; Clements, J. A. (2001). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma". Genomics. 77 (3): 200–7. doi:10.1006/geno.2001.6629. PMID 11597145.
Toiyama, Y; Mizoguchi, A; Kimura, K; Hiro, J; Inoue, Y; Tutumi, T; Miki, C; Kusunoki, M (2007). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation". World journal of gastroenterology : WJG. 13 (19): 2717–21. PMC 4147121. PMID 17569141.
Suzuki, M; Mizuno, A (2004). "A novel human Cl(-) channel family related to Drosophila flightless locus". Journal of Biological Chemistry. 279 (21): 22461–8. doi:10.1074/jbc.M313813200. PMID 15010458.{{cite journal}}: CS1 maint: unflagged free DOI (link)
He, Y; Ramsay, A. J.; Hunt, M. L.; Whitbread, A. K.; Myers, S. A.; Hooper, J. D. (2008). "N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: Impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)". Biochemical Journal. 412 (1): 45–55. doi:10.1042/BJ20071722. PMID 18260827.
He, Y; Hryciw, D. H.; Carroll, M. L.; Myers, S. A.; Whitbread, A. K.; Kumar, S; Poronnik, P; Hooper, J. D. (2008). "The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels". Journal of Biological Chemistry. 283 (35): 24000–10. doi:10.1074/jbc.M803361200. PMC 3259790. PMID 18577513.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141540 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034714 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tweety family member 2". Retrieved 2014-09-11.

[1]

[2]

[3]

[4]

[5]

Function

References

Further reading