U.S. Route 5 Alternate (US 5 Alt.) in St. Johnsbury, Vermont, runs parallel to US 5. US 5 goes through the downtown area, while US 5 Alt. goes around the west side of the city. The road has three names: Main Street, Mt. Pleasant Street, and Hastings Street. The route, known as Main Street at this point, starts from its southern terminus at its junction with US 5, just north of US 5's interchange with I-91 (exit 20). The road goes up a winding hill before meeting US 2. Between its junctions with US 5 and US 2, US 5 Alt. is concurrent with US 2 Truck. US 2 goes west on Western Avenue, while US 5 Alt. continues north, concurrent with US 2. At the next intersection, US 2 turns east onto Eastern Avenue and US 5 Alt. continues on Main Street as the road turns slightly right. At Arnold Park, Main Street keeps right, while US 5 Alt. turns left onto Mt. Pleasant Street. After that, Mt. Pleasant Street keeps straight while US 5 Alt. veers right onto Hastings Street. The road keeps straight until its northern terminus at US 5 north of St. Johnsbury.
U.S. Route 5 Alternate (US 5 Alt.) in Newport, Vermont, runs parallel to US 5. US 5 goes through the downtown area, while US 5 Alt. goes around the southeast side of the city. The road that US 5 Alt. is on only carries the name of Coventry Street. This route starts from its southern terminus at its junction with US 5, near the edge of the city limits. The road goes northeast and meets with the South Bay on the east side. US 5 Alt. continues straight after intersecting with 2nd Street. Before the next intersection, US 5 turns northwest still as Coventry Street entering the Newport urban area. The road keeps straight until its northern terminus at US 5 in downtown Newport.
U.S. Route 5 Alternate (US 5 Alt.) in Derby Line, Vermont, is an alternate way to reach Canada from US 5. The road that US 5 Alt. is on only carries the name of Caswell Avenue. This route starts from its southern terminus at its junction with US 5 in downtown Derby Line. This road then travels east to Interstate 91 (I-91). At I-91, US 5 Alt. merges with the I-91 northbound continuing until its northern terminus at the Canada–United States border. The road continues north as Autoroute 55 in Quebec, Canada.
^ abcTraffic Research Unit (May 2013). "2012 (Route Log) AADTs for State Highways"(PDF). Policy, Planning and Intermodal Development Division, Vermont Agency of Transportation. Retrieved March 8, 2015.