UACA

UACA
Identifiers
Aliases	UACA, NUCLING, uveal autoantigen with coiled-coil domains and ankyrin repeats
External IDs	OMIM: 612516; MGI: 1919815; HomoloGene: 74297; GeneCards: UACA; OMA:UACA - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	70,763,558 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	60,787,652 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; pancreatic ductal cell; ; sural nerve; ; cardia; ; renal medulla; ; ventral tegmental area; ; pylorus; ; nipple; ; trigeminal ganglion; ; subthalamic nucleus;
	Top expressed in
	otolith organ; ; ankle; ; utricle; ; muscle of thigh; ; tibialis anterior muscle; ; lumbar spinal ganglion; ; esophagus; ; medial head of gastrocnemius muscle; ; skeletal muscle tissue; ; knee joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	extracellular region; extracellular exosome; cytoskeleton; nucleus; cytoplasm; cytosol;
Biological process	apoptotic signaling pathway; regulation of NIK/NF-kappaB signaling; biological process;
	Sources:Amigo / QuickGO
Orthologs
	55075
	72565
	ENSG00000137831
	ENSMUSG00000034485
	Q9BZF9
	Q8CGB3
	NM_001008224; NM_018003
	NM_028283; NM_001357407; NM_001357408
	NP_001008225; NP_060473
	NP_082559; NP_001344336; NP_001344337
	Wikidata
View/Edit Human	View/Edit Mouse

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.^[5]^[6]^[7] Diseases associated with UACA include Graves' Disease.^[8] Among its related pathways are signaling by Rho GTPases and Intrinsic Pathway for Apoptosis. An important paralog of this gene is ANKRD24.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137831 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034485 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamada K, Senju S, Nakatsura T, Murata Y, Ishihara M, Nakamura S, et al. (February 2001). "Identification of a novel autoantigen UACA in patients with panuveitis". Biochemical and Biophysical Research Communications. 280 (4): 1169–1176. doi:10.1006/bbrc.2001.4189. PMID 11162650.
^ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281. doi:10.1093/dnares/7.4.271. PMID 10997877.
^ "Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats".
^ Ohkura T, Taniguchi S, Yamada K, Nishio N, Okamura T, Yoshida A, et al. (August 2004). "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease". Biochemical and Biophysical Research Communications. 321 (2): 432–440. doi:10.1016/j.bbrc.2004.06.162. PMID 15358194.
^ "UniProt". www.uniprot.org. Retrieved 2023-06-07.

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137831 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034485 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11162650-5] Yamada K, Senju S, Nakatsura T, Murata Y, Ishihara M, Nakamura S, et al. (February 2001). "Identification of a novel autoantigen UACA in patients with panuveitis". Biochemical and Biophysical Research Communications. 280 (4): 1169–1176. doi:10.1006/bbrc.2001.4189. PMID 11162650.

[pmid10997877-6] Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281. doi:10.1093/dnares/7.4.271. PMID 10997877.

[entrez-7] "Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats".

[8] Ohkura T, Taniguchi S, Yamada K, Nishio N, Okamura T, Yoshida A, et al. (August 2004). "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease". Biochemical and Biophysical Research Communications. 321 (2): 432–440. doi:10.1016/j.bbrc.2004.06.162. PMID 15358194.

[9] "UniProt". www.uniprot.org. Retrieved 2023-06-07.

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References

Further reading