UBXN6

UBXN6
Identifiers
Aliases	UBXN6, UBXD1, UBXDC2, UBX domain protein 6
External IDs	OMIM: 611946; MGI: 1913780; HomoloGene: 11538; GeneCards: UBXN6; OMA:UBXN6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 4,444,999 bp End 4,457,794 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 D Start 56,374,045 bp End 56,382,028 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis left adrenal cortex right adrenal gland right adrenal cortex anterior pituitary right frontal lobe blood right hemisphere of cerebellum right lobe of thyroid gland Top expressed in superior surface of tongue seminiferous tubule gallbladder spermatid spermatocyte muscle of thigh Ileal epithelium superior frontal gyrus dentate gyrus of hippocampal formation granule cell lip More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component extracellular exosome cytoskeleton nucleus microtubule organizing center cytoplasm extrinsic component of membrane lysosome lysosomal membrane endosome cytosol membrane early endosome membrane late endosome membrane protein-containing complex Biological process macroautophagy endosome to lysosome transport via multivesicular body sorting pathway ERAD pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80700 66530 Ensembl ENSG00000167671 ENSMUSG00000019578 UniProt Q9BZV1 Q99PL6 RefSeq (mRNA) NM_001171091 NM_025241 NM_024432 NM_001379361 NM_001379362 RefSeq (protein) NP_001164562 NP_079517 NP_077752 NP_001366290 NP_001366291 Location (UCSC) Chr 19: 4.44 – 4.46 Mb Chr 17: 56.37 – 56.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

UBX domain protein 6 is a protein in humans that is encoded by the UBXN6 gene.

Further reading

• Stapf C, Cartwright E, Bycroft M, Hofmann K, Buchberger A (November 2011). "The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors". The Journal of Biological Chemistry. 286 (44): 38670–8. doi:10.1074/jbc.M111.274472. PMC 3207395. PMID 21896481.
• Nagahama M, Ohnishi M, Kawate Y, Matsui T, Miyake H, Yuasa K, Tani K, Tagaya M, Tsuji A (May 2009). "UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation". Biochemical and Biophysical Research Communications. 382 (2): 303–8. doi:10.1016/j.bbrc.2009.03.012. PMID 19275885.
• Falsone SF, Gesslbauer B, Rek A, Kungl AJ (July 2007). "A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome". Proteomics. 7 (14): 2375–83. doi:10.1002/pmic.200600996. PMID 17623298. S2CID 29057711.
• Ritz D, Vuk M, Kirchner P, Bug M, Schütz S, Hayer A, Bremer S, Lusk C, Baloh RH, Lee H, Glatter T, Gstaiger M, Aebersold R, Weihl CC, Meyer H (August 2011). "Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations". Nature Cell Biology. 13 (9): 1116–23. doi:10.1038/ncb2301. PMC 3246400. PMID 21822278.
• Madsen L, Andersen KM, Prag S, Moos T, Semple CA, Seeger M, Hartmann-Petersen R (2008). "Ubxd1 is a novel co-factor of the human p97 ATPase". The International Journal of Biochemistry & Cell Biology. 40 (12): 2927–42. doi:10.1016/j.biocel.2008.06.008. PMID 18656546.
• Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ (September 2008). "UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover". Cell. 134 (5): 804–16. doi:10.1016/j.cell.2008.06.048. PMC 2614663. PMID 18775313.
• Kern M, Fernandez-Sáiz V, Schäfer Z, Buchberger A (March 2009). "UBXD1 binds p97 through two independent binding sites". Biochemical and Biophysical Research Communications. 380 (2): 303–7. doi:10.1016/j.bbrc.2009.01.076. PMID 19174149.
• Carim-Todd L, Escarceller M, Estivill X, Sumoy L (January 2001). "Identification and characterization of UBXD1, a novel UBX domain-containing gene on human chromosome 19p13, and its mouse ortholog". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1517 (2): 298–301. doi:10.1016/s0167-4781(00)00248-7. PMID 11342112.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BZV1 (UBX domain-containing protein 6) at the PDBe-KB.