UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase
| UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.91 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase (EC 2.6.1.91, pglE (gene)) is an enzyme with systematic name UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine + 2-oxoglutarate UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate
This enzyme is a pyridoxal-phosphate protein.
References
- ^ Olivier, N.B.; Chen, M.M.; Behr, J.R.; Imperiali, B. (2006). "In vitro biosynthesis of UDP-N,N′-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system". Biochemistry. 45: 13659–13669. doi:10.1021/bi061456h. PMID 17087520.
- ^ Schoenhofen, I.C.; McNally, D.J.; Vinogradov, E.; Whitfield, D.; Young, N.M.; Dick, S.; Wakarchuk, W.W.; Brisson, J.R.; Logan, S.M. (2006). "Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways". J. Biol. Chem. 281: 723–732. doi:10.1074/jbc.m511021200. PMID 16286454.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Rangarajan, E.S.; Ruane, K.M.; Sulea, T.; Watson, D.C.; Proteau, A.; Leclerc, S.; Cygler, M.; Matte, A.; Young, N.M. (2008). "Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni". Biochemistry. 47: 1827–1836. doi:10.1021/bi702032r. PMID 18198901.
- ^ Hartley, M.D.; Morrison, M.J.; Aas, F.E.; Borud, B.; Koomey, M.; Imperiali, B. (2011). "Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N′-diacetylbacillosamine". Biochemistry. 50: 4936–4948. doi:10.1021/bi2003372. PMID 21542610.
External links
- UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine+transaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)