UDP-N-acetylglucosamine enolpyruvyl transferase

UDP-N-acetylglucosamine enolpyruvyl transferase (or MurA) is an enzyme^[1] that catalyzes the first committed step in peptidoglycan biosynthesis, namely the ligation of phosphoenolpyruvate (PEP) to the 3'-hydroxyl group of UDP-N-acetylglucosamine. This pyruvate moiety provides the linker that bridges the glycan and peptide portion of peptidoglycan.^[2]

The enzyme is inhibited by the antibiotic fosfomycin, which covalently modifies an active site cysteine residue.^[3]

References

^ "Enolpyruvate transferase, EPT family". Retrieved 2008-11-23.
^ Brown ED, Vivas EI, Walsh CT, Kolter R (July 1995). "MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli". J. Bacteriol. 177 (14): 4194–7. PMC 177162. PMID 7608103.
^ King, Michael B. (2005). Lange Q & A. New York: McGraw-Hill, Medical Pub. Division. p. 298. ISBN 0-07-144578-1.

[urlEnolpyruvate_transferase,_EPT_family-1] "Enolpyruvate transferase, EPT family". Retrieved 2008-11-23.

[Brown-2] Brown ED, Vivas EI, Walsh CT, Kolter R (July 1995). "MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli". J. Bacteriol. 177 (14): 4194–7. PMC 177162. PMID 7608103.

[isbn0-07-144578-1-3] King, Michael B. (2005). Lange Q & A. New York: McGraw-Hill, Medical Pub. Division. p. 298. ISBN 0-07-144578-1.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)