UNC5A

UNC5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V2A
Identifiers
Aliases	UNC5A, UNC5H1, unc-5 netrin receptor A
External IDs	OMIM: 607869; MGI: 894682; HomoloGene: 41474; GeneCards: UNC5A; OMA:UNC5A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	176,880,898 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,153,831 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; primary visual cortex; ; right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex; ; superior frontal gyrus; ; Brodmann area 9; ; postcentral gyrus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; secondary oocyte; ; superior frontal gyrus; ; lumbar subsegment of spinal cord; ; hippocampus proper; ; humerus; ; transitional epithelium of urinary bladder; ; primary oocyte; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	netrin receptor activity;
Cellular component	intrinsic component of plasma membrane; integral component of membrane; neuronal cell body membrane; membrane raft; plasma membrane; cell projection; neuron projection membrane; membrane;
Biological process	multicellular organism development; neuron projection development; signal transduction; anterior/posterior axon guidance; axon guidance; apoptotic process; netrin-activated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	90249
	107448
	ENSG00000113763
	ENSMUSG00000025876
	Q6ZN44
	Q8K1S4
	NM_133369
	NM_153131; NM_001311128
	NP_588610
	NP_001298057; NP_694771
	Wikidata
View/Edit Human	View/Edit Mouse

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.^[5]

Template:PBB Summary

Interactions

UNC5A has been shown to interact with MAGED1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113763 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025876 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
^ Williams, Megan E; Strickland Phyllis; Watanabe Ken; Hinck Lindsay (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19). United States: 17483–90. doi:10.1074/jbc.M300415200. ISSN 0021-9258. PMID 12598531. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading