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Protein UPF2 PDB 1uw4.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases UPF2, HRENT2, smg-3, UPF2 regulator of nonsense transcripts homolog (yeast)
External IDs MGI: 2449307 HomoloGene: 6101 GeneCards: UPF2
RNA expression pattern
PBB GE UPF2 203519 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 11.92 – 12.04 Mb Chr 2: 5.95 – 6.06 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene.[3][4][5]


This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.[5]


UPF2 has been shown to interact with UPF1,[3][6][7][8][9] UPF3A[6][9] and UPF3B.[6][9][10][11]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Mendell JT, Medghalchi SM, Lake RG, Noensie EN, Dietz HC (Dec 2000). "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes". Molecular and Cellular Biology. 20 (23): 8944–57. doi:10.1128/MCB.20.23.8944-8957.2000. PMC 86549Freely accessible. PMID 11073994. 
  4. ^ Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE (Jan 2001). "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)". Molecular and Cellular Biology. 21 (1): 209–23. doi:10.1128/MCB.21.1.209-223.2001. PMC 88795Freely accessible. PMID 11113196. 
  5. ^ a b "Entrez Gene: UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)". 
  6. ^ a b c Lejeune F, Li X, Maquat LE (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413. 
  7. ^ Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW (Aug 2003). "Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells". The Biochemical Journal. 373 (Pt 3): 775–83. doi:10.1042/BJ20021920. PMC 1223536Freely accessible. PMID 12723973. 
  8. ^ Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (Sep 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes & Development. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC 312771Freely accessible. PMID 11544179. 
  9. ^ a b c Lykke-Andersen J, Shu MD, Steitz JA (Dec 2000). "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon". Cell. 103 (7): 1121–31. doi:10.1016/S0092-8674(00)00214-2. PMID 11163187. 
  10. ^ Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147Freely accessible. PMID 15231747. 
  11. ^ Lykke-Andersen J (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073Freely accessible. PMID 12417715. 

Further reading[edit]