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UPF3B

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UPF3B
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesUPF3B, HMRX62, MRXS14, RENT3B, UPF3X, Upf3p-X, UPF3BP1, UPF3BP2, UPF3BP3, UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3 regulator of nonsense transcripts homolog B, regulator of nonsense mediated mRNA decay, UPF3B regulator of nonsense mediated mRNA decay, MRX82
External IDsOMIM: 300298; MGI: 1915384; HomoloGene: 11307; GeneCards: UPF3B; OMA:UPF3B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

65109

68134

Ensembl

ENSG00000125351

ENSMUSG00000036572

UniProt

Q9BZI7

n/a

RefSeq (mRNA)

NM_023010
NM_080632

NM_026573

RefSeq (protein)

NP_075386
NP_542199

n/a

Location (UCSC)Chr X: 119.81 – 119.85 MbChr X: 37.09 – 37.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of nonsense transcripts 3B is a protein that in humans is encoded by the UPF3B gene.[5][6][7]

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Interactions

UPF3B has been shown to interact with UPF2[6][8][9][10] and UPF1.[6][9][11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125351 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036572 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE (Jan 2001). "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)". Mol Cell Biol. 21 (1): 209–23. doi:10.1128/MCB.21.1.209-223.2001. PMC 88795. PMID 11113196.
  6. ^ a b c Lykke-Andersen J, Shu MD, Steitz JA (Feb 2001). "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon". Cell. 103 (7): 1121–31. doi:10.1016/S0092-8674(00)00214-2. PMID 11163187.
  7. ^ "Entrez Gene: UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)".
  8. ^ Lehner, Ben; Sanderson Christopher M (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. ISSN 1088-9051. PMC 442147. PMID 15231747.
  9. ^ a b Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413.
  10. ^ Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.
  11. ^ Schell, Thomas; Köcher Thomas; Wilm Matthias; Seraphin Bertrand; Kulozik Andreas E; Hentze Matthias W (Aug 2003). "Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells". Biochem. J. 373 (Pt 3): 775–83. doi:10.1042/BJ20021920. ISSN 0264-6021. PMC 1223536. PMID 12723973.

Further reading

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