UQCRC2

UQCRC2
Identifiers
Aliases	UQCRC2, MC3DN5, QCR2, UQCR2, ubiquinol-cytochrome c reductase core protein II, ubiquinol-cytochrome c reductase core protein 2
External IDs	OMIM: 191329; MGI: 1914253; HomoloGene: 37764; GeneCards: UQCRC2; OMA:UQCRC2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	21,983,660 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	120,258,747 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; body of tongue; ; Skeletal muscle tissue of rectus abdominis; ; jejunal mucosa; ; apex of heart; ; duodenum; ; mucosa of sigmoid colon; ; rectum; ; muscle of thigh; ; biceps brachii;
	Top expressed in
	Paneth cell; ; myocardium of ventricle; ; medullary collecting duct; ; facial motor nucleus; ; substantia nigra; ; cardiac muscles; ; atrioventricular junction; ; cardiac muscle tissue of left ventricle; ; migratory enteric neural crest cell; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; zinc ion binding; metal ion binding; protein binding; catalytic activity; metalloendopeptidase activity; endopeptidase activity;
Cellular component	membrane; myelin sheath; nucleoplasm; mitochondrion; respirasome; extracellular exosome; mitochondrial inner membrane; mitochondrial respiratory chain complex III; mitochondrial respiratory chain complex IV; mitochondrial processing peptidase complex;
Biological process	proteolysis; aerobic respiration; oxidative phosphorylation; mitochondrial electron transport, ubiquinol to cytochrome c; protein processing involved in protein targeting to mitochondrion;
	Sources:Amigo / QuickGO
Orthologs
	7385
	67003
	ENSG00000140740
	ENSMUSG00000030884
	P22695
	Q9DB77
	NM_003366
	NM_025899
	NP_003357
	NP_080175
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome b-c1 complex subunit 2, mitochondrial is a protein that in humans is encoded by the UQCRC2 gene.^[5]^[6]^[7]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140740 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030884 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duncan AM, Ozawa T, Suzuki H, Rozen R (Feb 1994). "Assignment of the gene for the core protein II (UQCRC2) subunit of the mitochondrial cytochrome bc1 complex to human chromosome 16p12". Genomics. 18 (2): 455–6. doi:10.1006/geno.1993.1500. PMID 8288258.
^ Hosokawa Y, Suzuki H, Toda H, Nishikimi M, Ozawa T (Sep 1989). "Complementary DNA encoding core protein II of human mitochondrial cytochrome bc1 complex. Substantial diversity in deduced primary structure from its yeast counterpart". J Biol Chem. 264 (23): 13483–8. PMID 2547763.
^ "Entrez Gene: UQCRC2 ubiquinol-cytochrome c reductase core protein II".

References

Further reading