USP1

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USP1
Identifiers
AliasesUSP1, UBP, ubiquitin specific peptidase 1
External IDsMGI: 2385198 HomoloGene: 2528 GeneCards: USP1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for USP1
Genomic location for USP1
Band1p31.3Start62,436,297 bp[1]
End62,451,804 bp[1]
RNA expression pattern
PBB GE USP1 202413 s at fs.png

PBB GE USP1 202412 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003368
NM_001017415
NM_001017416

NM_001301414
NM_146144
NM_001356424

RefSeq (protein)

NP_001017415
NP_001017416
NP_003359

NP_001288343
NP_666256
NP_001343353

Location (UCSC)Chr 1: 62.44 – 62.45 MbChr 4: 98.92 – 98.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.[5][6]

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162607 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028560 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
  6. ^ a b "Entrez Gene: USP1 ubiquitin specific peptidase 1".

Further reading[edit]