USP36

USP36
Identifiers
Aliases	USP36, DUB1, ubiquitin specific peptidase 36
External IDs	OMIM: 612543; MGI: 1919594; HomoloGene: 11828; GeneCards: USP36; OMA:USP36 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	78,841,441 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,181,070 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; anterior pituitary; ; left ovary; ; right ovary; ; left uterine tube; ; body of pancreas; ; right hemisphere of cerebellum; ; skin of leg; ; skin of abdomen; ; gastric mucosa;
	Top expressed in
	Rostral migratory stream; ; zygote; ; genital tubercle; ; primitive streak; ; neural layer of retina; ; tail of embryo; ; lacrimal gland; ; muscle of thigh; ; epiblast; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiol-dependent deubiquitinase; peptidase activity; cysteine-type peptidase activity; hydrolase activity; RNA binding;
Cellular component	nucleolus; nucleus; nuclear speck;
Biological process	protein deubiquitination; regulation of autophagy of mitochondrion; ubiquitin-dependent protein catabolic process; positive regulation of protein targeting to mitochondrion; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	57602
	72344
	ENSG00000055483
	ENSMUSG00000033909
	Q9P275
	B1AQJ2
	NM_025090; NM_001321291
	NM_001033528
	NP_001308220
	NP_001028700
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene. ^[5] ^[6]

This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubuquitinate nucleophosmin and fibrillarin^[7] Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000055483 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033909 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346.
^ "Entrez Gene: USP36 ubiquitin specific peptidase 36".
^ Endo A, Matsumoto M, Inada T, Yamamoto A, Nakayama KI, Kitamura N, Komada M (Mar 2009). "Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36". J Cell Sci. 122 (Pt 5): 678–86. doi:10.1242/jcs.044461. PMID 19208757.