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User:Daask/sandbox/Tetrahydropalmatine as a substance abuse treatment

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Tetrahydropalmatine (THP) has been used as a substance abuse treatment, especially in the form of levo-tetrahydropalmatine (l-THP). l-THP is contained in plant species of the genera Stephania and Corydalis and herbal preparations derived from these plants. It has been approved for use in China under the trade name Rotundine.[1] THP is one of the active ingredients in Jinniu capsules, a Chinese pill formulation.[2] A comparison of Jinniu and lofexidine found no significant difference in their effects on acute heroin withdrawal symptoms.[2]


See also

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Citations

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References

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  • Shi, Jie; Xu, Guo-zhu; Liu, Ting-ting; Wang, Xi; Shen, Li-yang; Li, Jing; Hao, Wei; Chen, Hong-xian; Li, Su-xia; Lu, Lin (2008). "A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms". The American Journal of Drug and Alcohol Abuse. 34 (6). Informa UK Limited: 792–800. doi:10.1080/00952990802491563. ISSN 0095-2990. PMID 19016185. S2CID 27172036.


Further reading

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  • Cao, G., Zhang, Y., Zhu, L., Zhu, J., Zhao, N., Dong, N., ... & Chen, T. (2018). The inhibitory effect of levo-tetrahydropalmatine on the methamphetamine-induced spatial memory impairment in mice. Neuroscience letters, 672, 34-39. https://doi.org/10.1016/j.neulet.2018.02.018
  • Chen, Y. J., Liu, Y. L., Zhong, Q., Yu, Y. F., Su, H. L., Toque, H. A., ... & Chen, T. (2012). Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice. Neuroscience bulletin, 28(3), 222-232. https://doi.org/10.1007/s12264-012-1236-4
  • Chu, Hongyuan; Jin, Guozhang; Friedman, Eitan; Zhen, Xuechu (21 August 2007). "Recent Development in Studies of Tetrahydroprotoberberines: Mechanism in Antinociception and Drug Addiction". Cellular and Molecular Neurobiology. 28 (4). Springer Science and Business Media LLC: 491–499. doi:10.1007/s10571-007-9179-4. ISSN 0272-4340. PMID 17710533. S2CID 32614718.
  • Du, Y., Du, L., Cao, J., Hölscher, C., Feng, Y., Su, H., ... & Yun, K. M. (2017). Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats. Behavioural brain research, 317, 367-373. https://doi.org/10.1016/j.bbr.2016.10.001
  • Eldahshan, O. A.; Elsakka, A. M. A.; Singab, A. N. (2016). "Medicinal plants and addiction treatment". Medicinal & Aromatic Plants. 5 (4). OMICS Publishing Group. doi:10.4172/2167-0412.1000260. ISSN 2167-0412.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Faison, S. (2015). The Development of levo-Tetrahydropalmatine as a Treatment for Nicotine Addiction (Doctoral dissertation). http://hdl.handle.net/10713/4614
  • Faison, S. L. (2015). The development of levo-tetrahydropalmatine as a treatment for nicotine addiction (Order No. 3704571). Available from ProQuest Dissertations & Theses Global. (1687433202). Retrieved from https://search.proquest.com/docview/1687433202?accountid=11667
  • Faison, S. L., Schindler, C. W., Goldberg, S. R., & Wang, J. B. (2016). l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats. BMC Pharmacology & Toxicology, 17(1), 49. Retrieved from https://search.proquest.com/docview/1837031128?accountid=11667
  • Faison, S. L., Schindler, C. W., Goldberg, S. R., & Wang, J. B. (2016). l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats. BMC Pharmacology and Toxicology, 17(1), 49. https://doi.org/10.1186/s40360-016-0093-6
  • Figueroa-Guzman, Y., Mueller, C., Vranjkovic, O., Wisniewski, S., Yang, Z., Li, S. J., ... & Mantsch, J. R. (2011). Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats. Drug and alcohol dependence, 116(1-3), 72-79. https://doi.org/10.1016/j.drugalcdep.2010.11.023
  • Ge XQ, Zhang HQ, Zhou HZ, Xu ZG, Bian CF. Experimentalstudy of tetrahydroprotoberines inhibiting morphine withdrawalsyndromes. Chin J Drug Depend 1999; 8: 178–84
  • Gong, X., Yue, K., Ma, B., Xing, J., Gan, Y., Wang, D., . . . Li, C. (2016). Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement. Pharmacology Biochemistry and Behavior, 144, 67-72. doi:http://dx.doi.org/10.1016/j.pbb.2016.01.010
  • Gong, X., Yue, K., Ma, B., Xing, J., Gan, Y., Wang, D., . . . Li, C. (2016). Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement. Pharmacology, Biochemistry, and Behavior, 144, 67-72. doi:http://dx.doi.org/10.1016/j.pbb.2016.01.010
  • Jin GZ. Discoveries in the voyage of corydalis research. Shanghai:Shanghai Scientific & Technical Publishers; 2001.
  • Kim, T., Hinton, D. J., Johng, S., Wang, J. B., & Choi, D. S. (2013). Levo-tetrahydropalmatine decreases ethanol drinking and antagonizes dopamine D2 receptor-mediated signaling in the mouse dorsal striatum. Behavioural brain research, 244, 58-65. https://doi.org/10.1016/j.bbr.2013.01.028
  • S. Li(1), G. Xu(1), Q. Yin(1), G. Wu(1) and Z. Yang. (2006). Tetrahydropalmatine induces a negative BOLD signal in the nucleus accumbens andorbitofrontal cortex in heroin-dependent rats. https://cpdd.org/Pages/Meetings/Meetings_PDFs/2006meetingprogramnew2.pdf https://cpdd.org/wp-content/uploads/2015/04/2006abstractbook.pdf
  • Liu YL, Liang JH, Yan LD, Su RB, Wu CF, Gong ZH. Effects ofl-tetrahydropalmatine on locomotor sensitization to oxycodonein mice. Acta Pharmacol Sin 2005; 26: 533–8.
  • Liu, X. (2010). Pharmacological MRI investigation of levo-tetrahydropalmatine treatment mechanisms on drug addiction (Order No. 3415163). Available from ProQuest Dissertations & Theses Global. (614034514). Retrieved from https://search.proquest.com/docview/614034514?accountid=11667
  • Liu, X., Yang, Z., Li, R., Xie, J., Yin, Q., Bloom, A. S., & Li, S. (2012). Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in naive rats detected at 9.4 T. Magnetic Resonance Imaging, 30(2), 261-270. doi:http://dx.doi.org/10.1016/j.mri.2011.09.006
  • Liu, X., Yang, Z., Li, R., Xie, J., Yin, Q., Bloom, A. S., & Li, S. (2012). Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in naïve rats detected at 9.4 T. Magnetic Resonance Imaging, 30(2), 261-270. doi:http://dx.doi.org/10.1016/j.mri.2011.09.006
  • Liu, Y. L., Liang, J. H., Su, R. B., Wu, C. F., & Gong, Z. H. (2005). Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice. Acta Pharmacologica Sinica, 26(5), 533. https://doi.org/10.1111/j.1745-7254.2005.00101.x
  • Liu, Y., Yan, L., Zhou, P., Wu, C., & Gong, Z. (2009). Behavioural pharmacology: Levo-tetrahydropalmatine attenuates oxycodone-induced conditioned place preference in rats. European Journal of Pharmacology, 602(2-3), 321-327. doi:http://dx.doi.org/10.1016/j.ejphar.2008.11.031
  • Mantsch, John R.; Li, Shi-Jiang; Risinger, Robert; Awad, Sarah; Katz, Eric; Baker, David A.; Yang, Zheng (15 March 2007). "Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats". Psychopharmacology. 192 (4). Springer: 581–591. doi:10.1007/s00213-007-0754-7. ISSN 0033-3158. PMID 17361394. S2CID 23651147.
  • Mantsch, J. R., Wisniewski, S., Vranjkovic, O., Peters, C., Becker, A., Valentine, A., . . . Yang, Z. (2010). Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats. Pharmacology Biochemistry and Behavior, 97(2), 310-316. doi:http://dx.doi.org/10.1016/j.pbb.2010.08.016
  • Phillips, A., PhD. (2018). 15.5 tetrahydroprotoberberines (THPBs): An alternate pharmacotherapy for the treatment of addiction. Journal of the American Academy of Child and Adolescent Psychiatry, 57(10) Retrieved from https://search.proquest.com/docview/2133829763?accountid=11667
  • Qu, Y., & Qu, P. (1996). U.S. Patent No. 5,547,956. Washington, DC: U.S. Patent and Trademark Office. https://patents.google.com/patent/US5547956A/en
  • Shorter, D., & Kosten, T. R. (2011). Novel pharmacotherapeutic treatments for cocaine addiction. BMC medicine, 9(1), 119. https://doi.org/10.1186/1741-7015-9-119
  • Su, H. L., Zhu, J., Chen, Y. J., Zhao, N., Han, W., Dang, Y. H., ... & Chen, T. (2013). Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior. Physiology & behavior, 118, 195-200. https://doi.org/10.1016/j.physbeh.2013.05.034
  • Su, H., Sun, T., Wang, X., Du, Y., Zhao, N., Zhu, J., . . . Yun, K. (2020). Levo-tetrahydropalmatine attenuates methamphetamine reward behavior and the accompanying activation of ERK phosphorylation in mice. Neuroscience Letters, 714, 134416. doi:http://dx.doi.org/10.1016/j.neulet.2019.134416
  • Sushchyk, S. A. (2015). Llevo-tetrahydropalmatine (l-THP) and low dose naltrexone (LDN): A novel combination for the prevention of cocaine relapse (Order No. 3718988). Available from ProQuest Dissertations & Theses Global. (1712867591). Retrieved from https://search.proquest.com/docview/1712867591?accountid=11667
  • Sushchyk, S., Xi, Z. X., & Wang, J. B. (2016). Combination of levo-tetrahydropalmatine and low dose naltrexone: a promising treatment for prevention of cocaine relapse. Journal of Pharmacology and Experimental Therapeutics, 357(2), 248-257. https://doi.org/10.1124/jpet.115.229542
  • Sushchyk, S., Xi, Z., & Wang, J. B. (2016). Combination of levo-tetrahydropalmatine and low dose naltrexone: A promising treatment for prevention of cocaine relapse. The Journal of Pharmacology and Experimental Therapeutics, 357(2), 248-257. doi:http://dx.doi.org/10.1124/jpet.115.229542
  • Wang, J. B., & Mantsch, J. R. (2012). L-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. Future medicinal chemistry, 4(2), 177-186. https://doi.org/10.4155/fmc.11.166
  • Wang, L. (2011). Effects of levo-tetrahydropalmatine on methamphetamine induced locomotor sensitization and phosphorylation of erk in mice (Order No. 10542180). Available from ProQuest Dissertations & Theses Global. (1874889763). Retrieved from https://search.proquest.com/docview/1874889763?accountid=11667
  • Xi, Z. X., & Gardner, E. L. (2008). Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. Current drug abuse reviews, 1(3), 303-327.
  • Xi, Z. X., Yang, Z., Li, S. J., Li, X., Dillon, C., Peng, X. Q., ... & Gardner, E. L. (2007). Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology, 53(6), 771-782. https://doi.org/10.1016/j.neuropharm.2007.08.004
  • Yang, Z., Chen, H., Hao, W., Jin, G., & Li, S. (2006). Medication of L-tetrahydropalmatine increased the abstinence rate in heroin addicts. In College on Problems of Drug Dependence 2006 Meeting Abstracts, Scottsdale, AZ, Available at http://biopsych.com:81/CPDD06_Web/MeetProgAbSearch_06.html (Vol. 81). https://cpdd.org/Pages/Meetings/Meetings_PDFs/2006meetingprogramnew2.pdf https://cpdd.org/wp-content/uploads/2015/04/2006abstractbook.pdf
  • YANG, Z., SHAO, Y., LI, S., QI, J., ZHANG, M., HAO, W., & JIN, G. (2008). Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: A pilot study. Acta Pharmacologica Sinica, 29(7), 781-788. doi:http://dx.doi.org/10.1111/j.1745-7254.2008.00817.x
  • Yang, Z., Shao, Y., Li, S., Qi, J., Zhang, M., Hao, W., & Jin, G. (2008). Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: A pilot study. Acta Pharmacologica Sinica, 29(7), 781-8. doi:http://dx.doi.org/10.1111/j.1745-7254.2008.00817.x
  • Yu, M., Hassan, H. E., Ibrahim, A., Bauer, K. S., Kelly, D. L., & Jia, B. W. (2014). Simultaneous determination of l-tetrahydropalmatine and cocaine in human plasma by simple UPLC-FLD method: Application in clinical studies. Journal of Chromatography B, 965, 39-44. doi:http://dx.doi.org/10.1016/j.jchromb.2014.06.020
  • Yu, M., Hassan, H. E., Ibrahim, A., Bauer, K. S., Kelly, D. L., & Wang, J. B. (2014). Simultaneous determination of l-tetrahydropalmatine and cocaine in human plasma by simple UPLC–FLD method: Application in clinical studies. Journal of Chromatography B, 965, 39-44. https://doi.org/10.1016/j.jchromb.2014.06.020
  • Yue, Kai; Ma, Baomiao; Ru, Qin; Chen, Lin; Gan, Yongping; Wang, Daisong; Jin, Guozhang; Li, Chaoying (2012). "The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats". Pharmacology Biochemistry and Behavior. 102 (1). Elsevier: 1–5. doi:10.1016/j.pbb.2012.03.014. ISSN 0091-3057. PMID 22741173. S2CID 11965565.
  • Zhang, Y., Sha, R., Wang, K., Li, H., Yan, B., & Zhou, N. (2018). Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice. Molecular Medicine Reports, 17(5), 6873. doi:http://dx.doi.org/10.3892/mmr.2018.8700
  • Zhao, N., Chen, Y., Zhu, J., Wang, L., Cao, G., Dang, Y., ... & Chen, T. (2014). Levo-tetrahydropalmatine attenuates the development and expression of methamphetamine-induced locomotor sensitization and the accompanying activation of ERK in the nucleus accumbens and caudate putamen in mice. Neuroscience, 258, 101-110. https://doi.org/10.1016/j.neuroscience.2013.11.025