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Jin-Quan Yu | |
|---|---|
| Born | January 10, 1966 (age 58) |
| Nationality | American |
| Alma mater | East China Normal University (B.Sc., 1987) Guangzhou Institute of Chemistry (M.Sc., 1990) University of Cambridge (Ph.D., 1999) |
| Scientific career | |
| Fields | Chemistry |
| Institutions | Skaggs Institute for Chemical Biology Shanghai Institute of Organic Chemistry |
| Website | https://www.scripps.edu/yu/index.html |
Jin-Quan Yu (born 1966) is a Professor in the Department of Chemistry at Scripps Research[1]. He received his B.S. in Chemistry at East China Normal University. Following a one-year course study in Shanghai Institute of Organic Chemistry, he went to Guangzhou Institute of Chemistry, Chinese Academy of Sciences to study terpene chemistry and heterogeneous catalysis under the supervision of Professor Shu-De Xiao and obtained his Master’s degree in 1990. He stayed on as a research associate for four years and went to Cambridge University for his doctoral studies under the supervision of Prof. J. B. Spencer, where he studied biosynthesis and the mechanistic details of the hydrometallation step in asymmetric hydrogenation. He was elected as a Junior Research Fellow of St John’s College, Cambridge University in 1998. From 2001-2002, he worked on Pd-catalyzed allylic oxidation as a postdoctoral fellow at the Harvard University in the laboratories of Professor E. J. Corey. He returned to Cambridge University in 2002 and was appointed as a University Royal Society Research Fellow in 2003 to start his independent research towards developing asymmetric C–H insertion reactions. In 2004, he moved to Brandeis University as an Assistant Professor of Chemistry. He joined Scripps Research as an Associate Professor in 2007 and became a full Professor in August 2010.
In 2016, Jin-Quan Yu won the MacArthur Genius Grant for pioneering new methods for the catalysis and functionalization of carbon-hydrogen bonds.[2]
Awards and Honors
[edit]- Pedler award, Royal Society Chemistry, 2017
- MacArthur Genius Grant, 2016
- Elias J. Corey Award, American Chemical Scociety, 2014
- Raymond and Beverly Sackler Prize in the Physical Sciences, 2013
- Fellow of American Association for the Advancement of Science, 2012
- Fellow of the Royal Society of Chemistry, 2012
- Mukaiyama Award, Society of Organic Synthesis, Japan, 2012
- ACS Cope Scholar Award, 2012
Major contributions
[edit]Jin-Quan Yu is one of the leading researchers in the field of C-H activation. His research is mainly focused on the discovery of C-H activation reactions and their applications in drug discovery and natural product synthesis[3]. He has made several significant advances in the efficiency, specificity, and practicality of palladium-catalyzed C–H functionalization. He was the first one to combine weak coordination and ligand acceleration to promote C-H activation[4].
Using this approach, he has developed new ligands and strategies to achieve enantioselective and remote C-H activation reactions of synthetically relevant substrates in the past 15 years. Yu designed the first chiral ligand to enable asymmetric metal insertion to achieve enantioselective C-H activation[5]. In 2012, he developed an end-on template to enable meta-selective C-H activation[6]. A more recent strategy towards remote C-H activation— Norbornene-mediated meta-C-H activation was also discovered and developed by Yu[7].
His scientific articles have been published in Nature, Science, Nature Chemistry, Journal of the American Chemical Society and Angewandte Chemie International Edition. Being the most influential researchers in the field of C-H activation, Yu has published more than 200 papers and his papers on C-H activation alone were cited over 4,000 times per year.[8]
References
[edit]- ^ "Jin-Quan Yu | Scripps Research". www.scripps.edu. Retrieved 2018-11-30.
- ^ "Jin-Quan Yu - MacArthur Foundation". www.macfound.org. Retrieved 2018-11-30.
- ^ 2013, Megan Blewett - The Scripps Research Institute -. "The Yu Lab". www.scripps.edu. Retrieved 2018-11-30.
{{cite web}}:|last=has numeric name (help) - ^ Engle, Keary M.; Mei, Tian-Sheng; Wasa, Masayuki; Yu, Jin-Quan (2011-12-14). "Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions". Accounts of Chemical Research. 45 (6): 788–802. doi:10.1021/ar200185g. ISSN 0001-4842. PMC 3334399. PMID 22166158.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Saint-Denis, Tyler G.; Zhu, Ru-Yi; Chen, Gang; Wu, Qing-Feng; Yu, Jin-Quan (2018-02-16). "Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts". Science. 359 (6377): eaao4798. doi:10.1126/science.aao4798. ISSN 0036-8075. PMC 5862070. PMID 29449462.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Leow, Dasheng; Li, Gang; Mei, Tian-Sheng; Yu, Jin-Quan (2012-06). "Activation of remote meta-C–H bonds assisted by an end-on template". Nature. 486 (7404): 518–522. doi:10.1038/nature11158. ISSN 0028-0836. PMC 3386562. PMID 22739317.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: PMC format (link) - ^ Wang, Xiao-Chen; Gong, Wei; Fang, Li-Zhen; Zhu, Ru-Yi; Li, Suhua; Engle, Keary M.; Yu, Jin-Quan (2015-03). "Ligand-enabled meta-C–H activation using a transient mediator". Nature. 519 (7543): 334–338. doi:10.1038/nature14214. ISSN 0028-0836. PMC 4368492. PMID 25754328.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: PMC format (link) - ^ "jin-quan yu - Google Scholar Citations". scholar.google.com. Retrieved 2018-11-30.