User:Jilliaaaane/sandbox
| nucleoside phosphate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.4.4 | ||||||||
| CAS no. | 9026-50-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a nucleoside-phosphate kinase (EC 2.7.4.4) is an enzyme that catalyzes the chemical reaction
- ATP + nucleoside phosphate ADP + nucleoside diphosphate
Thus, the two substrates of this enzyme are ATP and nucleoside phosphate, whereas its two products are ADP and nucleoside diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:nucleoside-phosphate phosphotransferase. This enzyme is also called NMP-kinase. This enzyme participates in pyrimidine metabolism.
Structural studies
[edit]As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BND, 2BNE, and 2BNF.
References
[edit]- AYENGAR P, GIBSON DM, SANADI DR (1956). "Transphosphorylations between nucleoside phosphates". Biochim. Biophys. Acta. 21 (1): 86–91. doi:10.1016/0006-3002(56)90096-8. PMID 13363863.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - HEPPEL LA, STROMINGER JL, MAXWELL ES (1959). "Nucleoside monophosphate kinases. II. Transphosphorylation between adenosine monophosphate and nucleoside triphosphates". Biochim. Biophys. Acta. 32: 422–30. doi:10.1016/0006-3002(59)90615-8. PMID 14401179.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - LIEBERMAN I, KORNBERG A, SIMMS ES (1955). "Enzymatic synthesis of nucleoside diphosphates and triphosphates". J. Biol. Chem. 215 (1): 429–40. PMID 14392176.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 139-149.
- Berg, J.M.; Tymoczko, J.L.; Stryer, L. (2002). Biochemistry. New York: W H Freeman. ISBN 0-7167-3051-0. Retrieved 3/4/13.
{{cite book}}: Check date values in:|accessdate=(help) - Fukami-Kobayashi, Kaoru; Nosaka, Michiko; Nakazawa, Atsushi; Gō, Mitiko (1996). "Ancient Divergence of long and short isoforms of adenylate kinase molecular evolution of the nucleoside monophosphate kinase family". FEBS Letters. 385 (3): 214–220. Retrieved March 4, 2013.
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