User:Mr. Ibrahem/Atovaquone

From Wikipedia, the free encyclopedia
Mr. Ibrahem/Atovaquone
Clinical data
Trade namesMepron
AHFS/Drugs.comMonograph
MedlinePlusa693003
Routes of
administration		By mouth
Drug classAntiprotozoal[1]
Legal status
Legal status
Pharmacokinetic data
Elimination half-life2.2–3.2 days
Identifiers
  • trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
Chemical and physical data
FormulaC22H19ClO3
Molar mass366.84 g·mol−1
3D model (JSmol)
Melting point216 to 219 °C (421 to 426 °F)
  • OC=2C(=O)c1ccccc1C(=O)C=2[C@@H]3CC[C@H](CC3)c4ccc(Cl)cc4
  • InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,26H,5-8H2/t13-,15- checkY
  • Key:KUCQYCKVKVOKAY-CTYIDZIISA-N checkY
 ☒NcheckY (what is this?)  (verify)

Atovaquone, sold under the brand name Mepron, is an medication used to treat and prevent Pneumocystis jirovecii pneumonia (PCP), toxoplasmosis and babesiosis.[3][1] For PCP it is used in those who cannot take trimethoprim/sulfamethoxazole.[3] It is taken by mouth.[3]

Common side effects include headache, fever, anxiety, trouble sleeping, vivid dreams, nausea, diarrhea, skin rash, and itching.[4] Other side effects may include liver problems and angioedema.[3] Safety in pregnancy and breastfeeding is unclear.[5] It is a quinone, specifically a naphthoquinone.[4][3]

Atovaquone was approved for medical use in the United States in 1992.[4] It is available as a generic medication.[6] In the United Kingdom 50 doses of 750 mg costs the NHS about £470 as of 2021.[6] This amount in the United States is about 220 USD.[7]

References[edit]

  1. ^ a b "Atovaquone Monograph for Professionals". Drugs.com. Archived from the original on 3 June 2021. Retrieved 16 January 2022.
  2. ^ "Wellvone 750mg/5ml oral suspension - Summary of Product Characteristics (SmPC)". (emc). 28 November 2019. Archived from the original on 24 October 2020. Retrieved 18 September 2020.
  3. ^ a b c d e f "Atovaquone Oral SUSPENSION- atovaquone suspension". DailyMed. 10 December 2019. Archived from the original on 7 August 2020. Retrieved 18 September 2020.
  4. ^ a b c d "Atovaquone". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 16 January 2022.
  5. ^ "Atovaquone (Mepron) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 16 January 2022.
  6. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 641. ISBN 978-0857114105.
  7. ^ "Atovaquone Prices and Atovaquone Coupons - GoodRx". GoodRx. Retrieved 16 January 2022.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Atovaquone&oldid=1100868878"