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User:Mr. Ibrahem/Ceftolozane/tazobactam

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Mr. Ibrahem/Ceftolozane/tazobactam
Combination of
CeftolozaneCephalosporin antibiotic
TazobactamBeta-lactamase inhibitor
Clinical data
Trade namesZerbaxa
AHFS/Drugs.comMonograph
MedlinePlusa615010
License data
Pregnancy
category
Routes of
administration		Intravenous
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only
  • EU: Rx-only[2]
  • In general: ℞ (Prescription only)
Chemical and physical data
FormulaC23H30N12O8S2
Molar mass666.69 g·mol−1
3D model (JSmol)
  • CC(C)(C(=O)O)O/N=C(/c1nc(sn1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[n+]4cc(c(n4C)N)NC(=O)NCCN)C(=O)[O-]
  • InChI=1S/C23H30N12O8S2/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42)/b31-11-/t12-,18-/m1/s1
  • Key:JHFNIHVVXRKLEF-DCZLAGFPSA-N

Ceftolozane/tazobactam, sold under the brand name Zerbaxa, is a combination antibiotic used to treat complicated urinary tract infections, hospital acquired pneumonia, and complicated intra-abdominal infections.[3] For intra-abdominal infections it is used together with metronidazole.[3] It is given by injection into a vein.[2]

Common side effects include nausea, headache, constipation, diarrhea, and fever.[2] Other side effects may include anaphylaxis and Clostridioides difficile infection.[4] Ceftolozane is a cephalosporin, which disrupts the bacterial cell wall, while tazobactam blocks the activity of β-lactamase, which protects ceftolozane from degradation.[2]

The combination was approved for medical use in the United States in 2014 and Europe in 2015.[3][2] It is on the World Health Organization's List of Essential Medicines.[5] In the United Kingdom 10 doses of 1.5 grams costs the NHS about £670 as of 2021.[6] In the United States this amount is about 1,300 USD.[7]

References

[edit]
  1. ^ "Ceftolozane / tazobactam (Zerbaxa) Use During Pregnancy". Drugs.com. 14 June 2019. Archived from the original on 25 November 2020. Retrieved 14 May 2020.
  2. ^ a b c d e f "Zerbaxa EPAR". European Medicines Agency (EMA). Archived from the original on 6 May 2020. Retrieved 14 May 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  3. ^ a b c d "Zerbaxa- ceftolozane and tazobactam injection, powder, lyophilized, for solution". DailyMed. 3 June 2019. Archived from the original on 10 May 2020. Retrieved 14 May 2020.
  4. ^ "Ceftolozane/Tazobactam Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 2 January 2022.
  5. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  6. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 561. ISBN 978-0857114105.
  7. ^ "Zerbaxa Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 15 April 2021. Retrieved 2 January 2022.
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