User:Mr. Ibrahem/Cyproheptadine
Clinical data | |
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Pronunciation | (/ˌsaɪproʊˈhɛptədiːn/[1] |
Trade names | Periactin, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682541 |
License data | |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | First-generation antihistamine[2][3] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | 96 to 99% |
Metabolism | Liver[5][6] Mostly CYP3A4 mediated. |
Elimination half-life | 8.6 hours[4] |
Excretion | Faecal (2-20%; 34% of this as unchanged drug) and renal (40%; none as unchanged drug)[5][6] |
Identifiers | |
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Chemical and physical data | |
Formula | C21H21N |
Molar mass | 287.406 g·mol−1 |
3D model (JSmol) | |
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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine primarily used to treat allergies.[2][3] This may include itchiness, hay fever, and hives.[3] It may also be used for serotonin syndrome.[7] It is taken by mouth.[2]
Common side effects include sleepiness, dizziness, agitation, and poor coordination.[2] Other side effects may include swelling, problems urinating, and increased weight.[3] There is no evidence of harm with use during pregnancy, however such use has not been well studied.[8] Care should be taken in those at risk of glaucoma.[3]
Cyproheptadine was patented in 1959 and came into medical use in 1961.[9] It is available as a generic medication.[10] In the United Kingdom 30 tablets of 4 mg costs the NHS about 6 pounds in 2020.[3] This amount in the United States costs about 10 USD.[10]
References[edit]
- ^ "Cyproheptadine". Dictionary.com Unabridged (Online). n.d.
- ^ a b c d e f "Cyproheptadine Hydrochloride Monograph for Professionals". Drugs.com. Archived from the original on 11 December 2018. Retrieved 19 November 2020.
- ^ a b c d e f g BNF 79. London: Pharmaceutical Press. March 2020. p. 292. ISBN 978-0857113658.
- ^ Gunja N, Collins M, Graudins A (2004). "A comparison of the pharmacokinetics of oral and sublingual cyproheptadine". Journal of Toxicology. Clinical Toxicology. 42 (1): 79–83. doi:10.1081/clt-120028749. PMID 15083941. S2CID 20196551.
- ^ a b "CYPROHEPTADINE HYDROCHLORIDE tablet [Boscogen, Inc.]" (PDF). DailyMed. Boscogen, Inc. November 2010. Archived from the original on 4 July 2013. Retrieved 26 October 2013.
- ^ a b "PRODUCT INFORMATION PERIACTIN® (cyproheptadine hydrochloride)" (PDF). Aspen Pharmacare Australia. Aspen Pharmacare Australia Pty Ltd. 17 November 2011. Archived from the original (PDF) on 29 October 2013. Retrieved 26 October 2013.
- ^ Boyer EW, Shannon M (March 2005). "The serotonin syndrome" (PDF). The New England Journal of Medicine. 352 (11): 1112–20. doi:10.1056/NEJMra041867. PMID 15784664. Archived (PDF) from the original on 2013-06-18.
- ^ "Cyproheptadine (Periactin) Use During Pregnancy". Drugs.com. Archived from the original on 25 November 2020. Retrieved 19 November 2020.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 547. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2020-09-19.
- ^ a b "Cyproheptadine". Archived from the original on 11 November 2016. Retrieved 19 November 2020.