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User:Mr. Ibrahem/Ibandronic acid

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Mr. Ibrahem/Ibandronic acid
Clinical data
Trade namesBoniva, Bonviva, Bondronat, others
Other namesIbandronate sodium
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth, intravenous
Legal status
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability0.6%
Protein binding90.9 to 99.5%
(concentration-dependent)
MetabolismNil
Elimination half-life10 to 60 hours
ExcretionKidney
Chemical and physical data
FormulaC9H23NO7P2
Molar mass319.231 g·mol−1
3D model (JSmol)
  • O=P(O)(O)C(O)(CCN(CCCCC)C)P(=O)(O)O
  • InChI=1S/C9H23NO7P2/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17) checkY
  • Key:MPBVHIBUJCELCL-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ibandronic acid, also known as ibandronate, is a medication used treat of osteoporosis, high calcium due to cancer, and bone metastases from breast cancer.[1][2] It may be taken by mouth or injection into a vein.[1]

Common side effects include heart burn, low calcium, weakness, headache, and fever.[2] Other side effects may include anaphylaxis, esophagitis, femur fracture, and osteonecrosis of the jaw.[2][3] It is a bisphosphonate and works by stopping bone breakdown by cells known as osteoclasts.[1][2]

Ibandronic acid was patented in 1986 by Boehringer Mannheim and approved for medical use in 1996.[4] It is available as a generic medication.[1] In the United Kingdom a 150 mg pill cost the NHS about £4.50 as of 2021.[1] This amount in the United States is about 12 USD.[5]

References

[edit]
  1. ^ a b c d e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 769. ISBN 978-0857114105.
  2. ^ a b c d "Bondronat". Archived from the original on 11 January 2021. Retrieved 24 November 2021.
  3. ^ "Ibandronate Monograph for Professionals". Drugs.com. Archived from the original on 11 December 2018. Retrieved 24 November 2021.
  4. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 523. ISBN 9783527607495. Archived from the original on 2021-03-18. Retrieved 2020-12-06.
  5. ^ "Ibandronate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 24 November 2021.
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