User:Mr. Ibrahem/Meprobamate

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Mr. Ibrahem/Meprobamate
Clinical data
Trade namesMiltown, Equanil, Meprospan, others
AHFS/Drugs.comMonograph
MedlinePlusa682077
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
Drug classCarbamate[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability?
MetabolismLiver
Onset of actionWithin an hour[2]
Elimination half-life10 hours
ExcretionKidney
Identifiers
  • [2-(carbamoyloxymethyl)-2-methyl-pentyl] carbamate
Chemical and physical data
FormulaC9H18N2O4
Molar mass218.250 g·mol−1
3D model (JSmol)
Density1.229 g/cm3
Melting point105 to 106 °C (221 to 223 °F)
Boiling point200 °C (392 °F) to 210 °C (410 °F)
  • O=C(N)OCC(C)(CCC)COC(N)=O
  • InChI=1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13) checkY
  • Key:NPPQSCRMBWNHMW-UHFFFAOYSA-N checkY
  (verify)

Meprobamate, sold under the brand name Miltown among others, is a medication used to treat anxiety and seizures, as well as for sedation.[2] It is taken by mouth.[2] Effects begin within an hour.[2] Evidence only supports short term use.[2]

Common side effects include nausea, palpitations, low blood pressure, sleepiness, poor coordination, and aplastic anemia.[2] Other side effects may include abuse and allergic reactions.[2] Use in pregnancy may harm the baby.[2] It is a carbamate.[1]

Meprobamate's medical use was discovered in 1905.[3] Its approval was withdrawn in Europe in 2012.[4] It is available as a generic medication.[5] In the United States it costs about 160 USD per month as of 2021.[6] In the United Kingdom it is only available by special order and is deemed to be a less suitable medication.[7]

References[edit]

  1. ^ a b Maronde, Robert F. (6 December 2012). Topics in Clinical Pharmacology and Therapeutics. Springer Science & Business Media. p. 420. ISBN 978-1-4612-4864-4. Archived from the original on 16 November 2021. Retrieved 16 November 2021.
  2. ^ a b c d e f g h i j k "Meprobamate Monograph for Professionals". Drugs.com. Archived from the original on 31 December 2019. Retrieved 16 November 2021.
  3. ^ Wallace, Edwin R.; Gach, John (13 April 2010). "History of Psychiatry and Medical Psychology: With an Epilogue on Psychiatry and the Mind-Body Relation". Springer Science & Business Media. Archived from the original on 16 November 2021. Retrieved 16 November 2021.
  4. ^ "Questions and answers on the suspension of the marketing uthorisations for oral meprobamate-containing medicines" (PDF). 2012-01-19. Archived (PDF) from the original on 2014-12-21. Retrieved 2012-01-20.
  5. ^ "Meprobamate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 November 2016. Retrieved 16 November 2021.
  6. ^ "Meprobamate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 November 2016. Retrieved 16 November 2021.
  7. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 365. ISBN 978-0857114105.
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