User:Mr. Ibrahem/Tolterodine

Mr. Ibrahem/Tolterodine
Clinical data
Trade names	Detrol, Detrusitol, others
AHFS/Drugs.com	Monograph
MedlinePlus	a699026
License data	US DailyMed: Tolterodine;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	77%
Protein binding	Approximately 96.3%
Elimination half-life	1.9–3.7 hours
Identifiers
	IUPAC name (S)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-methylphenol;
Chemical and physical data
Formula	C22H31NO
Molar mass	325.496 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccc(c(c1)[C@H](CCN(C(C)C)C(C)C)c2ccccc2)O;
	InChI InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1 ; Key:OOGJQPCLVADCPB-HXUWFJFHSA-N ;
	(verify)

Tolterodine, sold under the brand names Detrol among others, is medication used to treat frequent urination, urinary incontinence, or urinary urgency.^[2] Effects are seen within an hour.^[3] It is taken by mouth.^[3]

Common side effects include headache, dry mouth, constipation, and dizziness.^[3] Serious side effects may include angioedema, urinary retention, and QT prolongation.^[3] Use in pregnancy and breastfeeding are of unclear safety.^[2]^[4] It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions.^[3]

Tolterodine was approved for medical use in 1998.^[3] It is available as a generic medication.^[2] A month supply costs the NHS about GB£2.09 per month as of 2019.^[2] In the United States the wholesale cost of this amount is about US$37.16.^[5] In 2017, it was the 229th most commonly prescribed medication in the United States, with more than two million prescriptions.^[6]^[7]

References[edit]

^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 12 December 2020. Retrieved 9 September 2020.
^ ^a ^b ^c ^d British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 762. ISBN 9780857113382.
^ ^a ^b ^c ^d ^e ^f "Tolterodine Tartrate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 27 March 2019. Retrieved 3 March 2019.
^ "tolterodine Use During Pregnancy". Drugs.com. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
^ "Tolterodine Tartrate - Drug Usage Statistics". ClinCalc. Archived from the original on 4 July 2020. Retrieved 11 April 2020.

[WHO2020DDD-1] "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 12 December 2020. Retrieved 9 September 2020.

[BNF76-2] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 762. ISBN 9780857113382.

[AHFS2019-3] ^ ^a ^b ^c ^d ^e ^f "Tolterodine Tartrate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 27 March 2019. Retrieved 3 March 2019.

[Preg2019-4] "tolterodine Use During Pregnancy". Drugs.com. Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[NADAC2019-5] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-6] "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.

[ref1-7] "Tolterodine Tartrate - Drug Usage Statistics". ClinCalc. Archived from the original on 4 July 2020. Retrieved 11 April 2020.

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