User:Mr. Ibrahem/Ziconotide

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Mr. Ibrahem/Ziconotide
Clinical data
Trade namesPrialt, others
Other namesSNX–111
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intrathecal – directly into cerebrospinal fluid by a catheter
Legal status
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability50%
Elimination half-life2.9 to 6.5 hours
Excretion<1% urine
Chemical and physical data
FormulaC102H172N36O32S7
Molar mass2639.14 g·mol−1
3D model (JSmol)
  • C[C@H]1C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N3)CO)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CCCNC(=N)N)CC(C)C)CCSC)CC4=CC=C(C=C4)O)CC(=O)O)C(=O)N)CCCCN)CO)CCCNC(=N)N)CCCCN
  • InChI=1S/C102H172N36O32S7/c1-50(2)34-63-91(161)127-62(26-33-171-5)90(160)129-64(35-53-22-24-54(143)25-23-53)92(162)130-65(36-78(148)149)93(163)135-72-48-175-173-45-69(80(108)150)133-86(156)58(18-8-12-29-105)121-76(146)39-117-85(155)66(41-139)131-88(158)61(21-15-32-114-102(111)112)126-96(166)70-46-176-177-47-71(97(167)132-68(43-141)95(165)125-60(87(157)128-63)20-14-31-113-101(109)110)134-89(159)59(19-9-13-30-106)123-81(151)51(3)119-74(144)37-115-83(153)56(16-6-10-27-103)120-75(145)38-116-84(154)57(17-7-11-28-104)124-82(152)55(107)44-172-174-49-73(137-98(72)168)99(169)138-79(52(4)142)100(170)118-40-77(147)122-67(42-140)94(164)136-70/h22-25,50-52,55-73,79,139-143H,6-21,26-49,103-107H2,1-5H3,(H2,108,150)(H,115,153)(H,116,154)(H,117,155)(H,118,170)(H,119,144)(H,120,145)(H,121,146)(H,122,147)(H,123,151)(H,124,152)(H,125,165)(H,126,166)(H,127,161)(H,128,157)(H,129,160)(H,130,162)(H,131,158)(H,132,167)(H,133,156)(H,134,159)(H,135,163)(H,136,164)(H,137,168)(H,138,169)(H,148,149)(H4,109,110,113)(H4,111,112,114)/t51-,52+,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,79-/m0/s1 ☒N
  • Key:BPKIMPVREBSLAJ-QTBYCLKRSA-N ☒N
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Ziconotide, sold under the brand name Prialt among others, is a medication used for severe chronic pain.[1] It is given by injection into the space around the spinal cord.[1] Use is not recommended as of 2007 by NHS Scotland.[3] The dose used is generally slowly increased over 3 weeks.[1]

Common side effects include dizziness, confusion, headache, nystagmus, and sleepiness.[1][2] Serious side effects may include psychosis or meningitis.[1] It works by blocking neurons that sense pain by binding to N-type calcium channels.[1] It is not an opioid.[1]

Ziconotide was approved for medical use in the United States in 2004 and Europe in 2005.[1][2] It was originally made from the venom of the snail Conus magus.[1] Though is now a manufactured form of a ω-conotoxin peptide.[4] In 2012 45 days of medication cost about 730 USD to 4,400 USD in the United States.[5]

References[edit]

  1. ^ a b c d e f g h i j k "Ziconotide Monograph for Professionals". Drugs.com. Archived from the original on March 4, 2021. Retrieved August 4, 2021.
  2. ^ a b c "Prialt". Archived from the original on November 12, 2020. Retrieved August 4, 2021.
  3. ^ "ziconotide 100 micrograms/ml solution for infusion (Prialt)". Scottish Medicines Consortium. Archived from the original on August 27, 2021. Retrieved August 4, 2021.
  4. ^ "Prialt solution for infusion - Summary of Product Characteristics (SmPC) - (eMC)". Electronic Medicines Compendium. January 2017. Archived from the original on June 24, 2019. Retrieved April 21, 2018.
  5. ^ Webster, Lynn R.; Fakata, Keri L. "Ziconotide for Chronic Severe Pain". Practical Pain Management. Archived from the original on January 19, 2021. Retrieved August 4, 2021.
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