VAV3

VAV3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D86
Identifiers
Aliases	VAV3, vav guanine nucleotide exchange factor 3
External IDs	OMIM: 605541; MGI: 1888518; HomoloGene: 38143; GeneCards: VAV3; OMA:VAV3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	107,965,180 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	109,593,014 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; skin of thigh; ; gingival epithelium; ; skin of hip; ; secondary oocyte; ; kidney tubule; ; tibia; ; rectum; ; palpebral conjunctiva; ; hair follicle;
	Top expressed in
	habenula; ; hair follicle; ; medullary collecting duct; ; medial dorsal nucleus; ; granulocyte; ; medial geniculate nucleus; ; spermatid; ; conjunctival fornix; ; Paneth cell; ; lateral geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; epidermal growth factor receptor binding; GTPase activator activity; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; plasma membrane;
Biological process	angiogenesis; Fc-gamma receptor signaling pathway involved in phagocytosis; intracellular signal transduction; ephrin receptor signaling pathway; lamellipodium assembly; regulation of Rho protein signal transduction; positive regulation of phosphatidylinositol 3-kinase activity; vascular endothelial growth factor receptor signaling pathway; small GTPase mediated signal transduction; B cell receptor signaling pathway; cell projection assembly; Fc-epsilon receptor signaling pathway; positive regulation of apoptotic process; integrin-mediated signaling pathway; cellular response to DNA damage stimulus; regulation of cell size; regulation of small GTPase mediated signal transduction; cell migration; platelet activation; vesicle fusion; positive regulation of cell adhesion; positive regulation of B cell proliferation; neutrophil chemotaxis; regulation of GTPase activity; positive regulation of signal transduction; positive regulation of GTPase activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10451
	57257
	ENSG00000134215
	ENSMUSG00000033721
	Q9UKW4
	Q9R0C8
	NM_001079874; NM_006113
	NM_020505; NM_146139; NM_001378987
	NP_001073343; NP_006104
	NP_065251; NP_666251; NP_001365916
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.^[5]

Template:PBB Summary

Interactions

VAV3 has been shown to interact with Grb2.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134215 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033721 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: VAV3 vav 3 oncogene".
^ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3). United States: 315–318. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (December 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24). UNITED STATES: 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179. PMID 11094073. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading