VAV3

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VAV3
Protein VAV3 PDB 2d86.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VAV3
External IDs MGI: 1888518 HomoloGene: 38143 GeneCards: VAV3
Genetically Related Diseases
hypothyroidism[1]
RNA expression pattern
PBB GE VAV3 218806 s at fs.png

PBB GE VAV3 218807 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001079874
NM_006113

NM_020505
NM_146139

RefSeq (protein)

NP_001073343
NP_006104

NP_065251.2
NP_666251.1
NP_065251
NP_666251

Location (UCSC) Chr 1: 107.57 – 107.97 Mb Chr 3: 109.34 – 109.69 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.[4]

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[4]

Interactions[edit]

VAV3 has been shown to interact with Grb2.[5][6]

References[edit]

  1. ^ "Diseases that are genetically associated with VAV3 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: VAV3 vav 3 oncogene". 
  5. ^ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. United States. 21 (3): 315–318. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. 
  6. ^ Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (December 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. UNITED STATES. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179Freely accessible. PMID 11094073. 

Further reading[edit]