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VCF may refer to:
- Vaginal contraceptive film, a type of spermicide birth control
- Valencia CF, a Spanish football club in La Liga
- Variant Call Format, a standard for storing gene sequence variations
- vCard, a file format standard for electronic business cards (.vcf)
- Vertebral compression fracture, a collapse of a vertebra
- September 11th Victim Compensation Fund
- Victory Christian Fellowship, an organization of churches in the Philippines
- Vietnam Children's Fund
- Vintage Computer Festival, an annual event in Mountain View, California, and other locations
- Virtual Case File, a defunct software system developed by the US FBI
- Visual Component Framework, an open source C++ application framework
- Voltage-controlled filter, a signal processing device in an analog synthesizer
| disambiguation page lists articles associated with the title VCF.
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