VNN2

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VNN2
Identifiers
Aliases VNN2, FOAP-4, GPI-80, vanin 2
External IDs HomoloGene: 130041 GeneCards: VNN2
RNA expression pattern
PBB GE VNN2 205922 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242350
NM_004665
NM_078488

n/a

RefSeq (protein)

NP_001229279
NP_004656
NP_511043

n/a

Location (UCSC) Chr 6: 132.74 – 132.76 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Vascular non-inflammatory molecule 2 is a protein that in humans is encoded by the VNN2 gene.[2][3][4]

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769. 
  3. ^ Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F (Aug 2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533. 
  4. ^ a b "Entrez Gene: VNN2 vanin 2". 

Further reading[edit]