VPS4B

VPS4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WR0, 1XWI, 2CPT, 2JQH, 2JQK, 4U7Y
Identifiers
Aliases	VPS4B, SKD1, SKD1B, VPS4-2, MIG1, vacuolar protein sorting 4 homolog B
External IDs	OMIM: 609983; MGI: 1100499; HomoloGene: 37976; GeneCards: VPS4B; OMA:VPS4B - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	63,422,483 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	106,724,458 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; amniotic fluid; ; epithelium of nasopharynx; ; secondary oocyte; ; gingival epithelium; ; mucosa of ileum; ; oral cavity; ; Achilles tendon; ; palpebral conjunctiva; ; hair follicle;
	Top expressed in
	conjunctival fornix; ; ciliary body; ; Paneth cell; ; lacrimal gland; ; hair follicle; ; primitive streak; ; iris; ; vestibular sensory epithelium; ; medullary collecting duct; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; ATPase activity; protein C-terminus binding; protein binding; identical protein binding; hydrolase activity; ATP binding;
Cellular component	cytoplasm; cytosol; endosome; centrosome; spindle pole; membrane; late endosome membrane; Flemming body; endosome membrane; extracellular exosome; nucleus;
Biological process	late endosomal microautophagy; regulation of centrosome duplication; protein depolymerization; viral budding via host ESCRT complex; viral life cycle; nucleus organization; cholesterol transport; negative regulation of exosomal secretion; multivesicular body assembly; negative regulation of cell death; regulation of mitotic spindle assembly; endosome organization; cell division; positive regulation of centriole elongation; endosomal transport; potassium ion transport; response to lipid; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway; protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of exosomal secretion; septum digestion after cytokinesis; mitotic metaphase plate congression; endosome to lysosome transport via multivesicular body sorting pathway; cell cycle; ESCRT III complex disassembly; macroautophagy; transport; positive regulation of viral process; vacuole organization; midbody abscission;
	Sources:Amigo / QuickGO
Orthologs
	9525
	20479
	ENSG00000119541
	ENSMUSG00000009907
	O75351
	P46467
	NM_004869
	NM_009190
	NP_004860; NP_004860.2
	NP_033216
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009907 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
^ "Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)".

References

Further reading