VPS4B

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VPS4B
Protein VPS4B PDB 1wr0.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VPS4B, SKD1, SKD1B, VPS4-2, MIG1, vacuolar protein sorting 4 homolog B
External IDs MGI: 1100499 HomoloGene: 37976 GeneCards: 9525
RNA expression pattern
PBB GE VPS4B 218171 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004869

NM_009190

RefSeq (protein)

NP_004860.2
NP_004860.2

NP_033216.2

Location (UCSC) Chr 18: 63.39 – 63.42 Mb Chr 1: 106.76 – 106.8 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.[1][2]

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.[2]

References[edit]

  1. ^ Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910. 
  2. ^ a b "Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)". 

Further reading[edit]