L-tryptophan—pyruvate aminotransferase

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L-tryptophan---pyruvate aminotransferase
EC number
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ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

L-tryptophan---pyruvate aminotransferase (EC, TAA1 (gene), vt2 (gene)) is an enzyme with systematic name L-tryptophan:pyruvate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

L-tryptophan + pyruvate indole-3-pyruvate + L-alanine

This plant enzyme, along with EC, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.


  1. ^ Tao, Y.; Ferrer, J.L.; Ljung, K.; Pojer, F.; Hong, F.; Long, J.A.; Li, L.; Moreno, J.E.; Bowman, M.E.; Ivans, L.J.; Cheng, Y.; Lim, J.; Zhao, Y.; Ballare, C.L.; Sandberg, G.; Noel, J.P.; Chory, J. (2008). "Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants". Cell. 133: 164–176. doi:10.1016/j.cell.2008.01.049. PMC 2442466Freely accessible. PMID 18394996. 
  2. ^ Mashiguchi, K.; Tanaka, K.; Sakai, T.; Sugawara, S.; Kawaide, H.; Natsume, M.; Hanada, A.; Yaeno, T.; Shirasu, K.; Yao, H.; McSteen, P.; Zhao, Y.; Hayashi, K.; Kamiya, Y.; Kasahara, H. (2011). "The main auxin biosynthesis pathway in Arabidopsis". Proc. Natl. Acad. Sci. USA. 108: 18512–18517. doi:10.1073/pnas.1108434108. PMC 3215075Freely accessible. PMID 22025724. 
  3. ^ Phillips, K.A.; Skirpan, A.L.; Liu, X.; Christensen, A.; Slewinski, T.L.; Hudson, C.; Barazesh, S.; Cohen, J.D.; Malcomber, S.; McSteen, P. (2011). "vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize". Plant Cell. 23: 550–566. doi:10.1105/tpc.110.075267. PMID 21335375. 
  4. ^ Zhao, Y. (2012). "Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants". Mol. Plant. 5: 334–338. doi:10.1093/mp/ssr104. PMC 3309920Freely accessible. PMID 22155950. 

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