Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family. GEF activity is mediated via module of tandem DH-PH domains. Vav proteins also appear to exhibit GEF-independent functions. Although it was originally thought that Vav proteins would only be present in multicellular organisms, Vav family proteins have been observed in Choanoflagellates.
In humans there are three Vav proteins:
- Bustelo, X. R. (March 2000). "Regulatory and Signaling Properties of the Vav Family". Molecular and Cellular Biology. 20 (5): 1461–1477. doi:10.1128/MCB.20.5.1461-1477.2000. PMC . PMID 10669724.
- Bustelo, Xosé R (November 2014). "Vav family exchange factors: an integrated regulatory and functional view". Small GTPases. 5 (2): e973757. doi:10.4161/21541248.2014.973757. PMC . PMID 25483299.
|This protein-related article is a stub. You can help Wikipedia by expanding it.|