Vav (protein)

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Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family.[1][2] GEF activity is mediated via module of tandem DH-PH domains. Vav proteins also appear to exhibit GEF-independent functions. Although it was originally thought that Vav proteins would only be present in multicellular organisms,[1] Vav family proteins have been observed in Choanoflagellates.[2]

In humans there are three Vav proteins:


  1. ^ a b Bustelo, X. R. (March 2000). "Regulatory and Signaling Properties of the Vav Family". Molecular and Cellular Biology. 20 (5): 1461–1477. doi:10.1128/MCB.20.5.1461-1477.2000. PMC 85310Freely accessible. PMID 10669724. 
  2. ^ a b Bustelo, Xosé R (November 2014). "Vav family exchange factors: an integrated regulatory and functional view". Small GTPases. 5 (2): e973757. doi:10.4161/21541248.2014.973757. PMC 4601183Freely accessible. PMID 25483299.