WARS (gene)

WARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O5T, 1R6T, 1R6U, 1ULH, 2AKE, 2AZX, 2DR2, 2QUH, 2QUI, 2QUJ, 2QUK
Identifiers
Aliases	WARS1, Tryptophanyl-tRNA synthetase, cytoplasmic, GAMMA-2, IFI53, IFP53, tryptophanyl-tRNA synthetase, HMN9, tryptophanyl-tRNA synthetase 1, WARS
External IDs	OMIM: 191050; MGI: 104630; HomoloGene: 3084; GeneCards: WARS1; OMA:WARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	100,376,805 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	108,860,100 bp
RNA expression pattern
	Top expressed in
	monocyte; ; upper lobe of left lung; ; right lung; ; appendix; ; islet of Langerhans; ; rectum; ; stromal cell of endometrium; ; smooth muscle tissue; ; left ventricle; ; lymph node;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; seminal vesicula; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; medulla oblongata; ; pontine nuclei; ; neural tube; ; entorhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein binding; ATP binding; tryptophan-tRNA ligase activity; kinase inhibitor activity; protein kinase binding; protein domain specific binding; protein homodimerization activity;
Cellular component	extracellular exosome; nucleus; cytoplasm; cytosol; protein-containing complex;
Biological process	regulation of angiogenesis; protein biosynthesis; tRNA aminoacylation for protein translation; angiogenesis; negative regulation of cell population proliferation; tryptophanyl-tRNA aminoacylation; negative regulation of protein phosphorylation; negative regulation of protein kinase activity; positive regulation of gene expression; regulation of protein ADP-ribosylation; positive regulation of protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	7453
	22375
	ENSG00000140105
	ENSMUSG00000021266
	P23381
	P32921
	NM_004184; NM_173701; NM_213645; NM_213646
	NM_001164314; NM_001164488; NM_011710
	NP_004175; NP_776049; NP_998810; NP_998811
	NP_001157786; NP_001157960; NP_035840
	Wikidata
View/Edit Human	View/Edit Mouse

Tryptophanyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the WARS gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140105 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021266 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Buwitt U, Flohr T, Bottger EC (Mar 1992). "Molecular cloning and characterization of an interferon induced human cDNA with sequence homology to a mammalian peptide chain release factor". EMBO J. 11 (2): 489–96. PMC 556479. PMID 1537332.
^ Fleckner J, Rasmussen HH, Justesen J (Feb 1992). "Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase". Proc Natl Acad Sci U S A. 88 (24): 11520–4. doi:10.1073/pnas.88.24.11520. PMC 53167. PMID 1763065.
^ "Entrez Gene: WARS tryptophanyl-tRNA synthetase".

References

Further reading