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Protein WASF2 PDB 2a40.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesWASF2, IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2, WAS protein family member 2, WASP family member 2
External IDsOMIM: 605875 MGI: 1098641 HomoloGene: 86743 GeneCards: WASF2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for WASF2
Genomic location for WASF2
Band1p36.11Start27,404,230 bp[1]
End27,490,167 bp[1]
RNA expression pattern
PBB GE WASF2 221725 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 27.4 – 27.49 MbChr 4: 133.13 – 133.2 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Wiskott-Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.[5]

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID 10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.[6]


WASF2 has been shown to interact with BAIAP2.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158195 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028868 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Suetsugu S, Miki H, Takenawa T (July 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem Biophys Res Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
  6. ^ "Entrez Gene: WASF2 WAS protein family, member 2".
  7. ^ Miki, H; Yamaguchi H; Suetsugu S; Takenawa T (December 2000). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature. 408 (6813): 732–5. doi:10.1038/35047107. ISSN 0028-0836. PMID 11130076.

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