WDR8

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WRAP73
Identifiers
Aliases WRAP73, WDR8, WD repeat containing, antisense to TP73
External IDs MGI: 1891749 HomoloGene: 9857 GeneCards: WRAP73
RNA expression pattern
PBB GE WDR8 219322 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017818

NM_021499

RefSeq (protein)

NP_060288

NP_067474.2
NP_067474

Location (UCSC) Chr 1: 3.63 – 3.65 Mb Chr 4: 154.14 – 154.17 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.[3]

Function[edit]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification.[3]

References[edit]

Further reading[edit]

  • Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y (March 2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family". Genomics. 72 (3): 252–9. doi:10.1006/geno.2000.6475. PMID 11401440. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.