WDR83

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WDR83
Identifiers
AliasesWDR83, MORG1, WD repeat domain 83
External IDsOMIM: 616850 MGI: 1915086 HomoloGene: 12194 GeneCards: WDR83
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for WDR83
Genomic location for WDR83
Band19p13.13Start12,666,802 bp[1]
End12,675,832 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099737
NM_032332

NM_026399

RefSeq (protein)

NP_001093207
NP_115708

NP_080675

Location (UCSC)Chr 19: 12.67 – 12.68 MbChr 8: 85.08 – 85.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene. [5]

Function[edit]

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123154 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005150 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: WD repeat domain 83". Retrieved 2017-06-15.

Further reading[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.