WNT1-inducible-signaling pathway protein 2

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Aliases WISP2, CCN5, CT58, CTGF-L, WNT1 inducible signaling pathway protein 2
External IDs MGI: 1328326 HomoloGene: 2882 GeneCards: WISP2
RNA expression pattern
PBB GE WISP2 205792 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 44.71 – 44.73 Mb Chr 2: 163.82 – 163.83 Mb
PubMed search [1] [2]
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WNT1-inducible-signaling pathway protein 2, or WISP-2 (also named CCN5) is a matricellular protein that in humans is encoded by the WISP2 gene.[3][4]


The CCN family of proteins regulates diverse cellular functions, including cell adhesion, migration, proliferation, differentiation.[5][6][7]


WISP-2 is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. The CCN acronym is derived from the first three members of the family identified, namely CYR61 (CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, together with WISP1/CCN4, WISP2 (CCN5, this gene), and WISP3 (CCN6) comprise the six-member CCN family in vertebrates. CCN proteins characteristically contain an N-terminal secretory signal peptide followed by four structurally distinct domains with homologies to insulin-like growth factor binding protein (IGFBP), von Willebrand type C repeats (vWC), thrombospondin type 1 repeat (TSR), and a cysteine knot motif within the C-terminal (CT) domain. However, WISP-2 is unique among this family of proteins by lacking precisely the CT domain.

Clinical significance[edit]

WISP-2 (CCN5) inhibits the proliferation of vascular smooth muscle cells,[8] human uterine myometrial cells, and leiomyoma cells.[9] Ectopic expression of WISP-2 also inhibits the motility and invasiveness of breast carcinoma cells.[10][11] WISP-2 also inhibits cardiac hypertrophy and fibrosis, an effect that appears linked to the absence of the CT domain.[12]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jun JI, Lau LF (Dec 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nature Reviews. Drug Discovery. 10 (12): 945–63. doi:10.1038/nrd3599. PMID 22129992. 
  4. ^ Russo JW, Castellot JJ (Oct 2010). "CCN5: biology and pathophysiology". Journal of Cell Communication and Signaling. 4 (3): 119–30. doi:10.1007/s12079-010-0098-7. PMC 2948116Freely accessible. PMID 21063502. 
  5. ^ Chen CC, Lau LF (Apr 2009). "Functions and mechanisms of action of CCN matricellular proteins". The International Journal of Biochemistry & Cell Biology. 41 (4): 771–83. doi:10.1016/j.biocel.2008.07.025. PMC 2668982Freely accessible. PMID 18775791. 
  6. ^ Holbourn KP, Acharya KR, Perbal B (Oct 2008). "The CCN family of proteins: structure-function relationships". Trends in Biochemical Sciences. 33 (10): 461–73. doi:10.1016/j.tibs.2008.07.006. PMC 2683937Freely accessible. PMID 18789696. 
  7. ^ Leask A, Abraham DJ (Dec 2006). "All in the CCN family: essential matricellular signaling modulators emerge from the bunker". Journal of Cell Science. 119 (Pt 23): 4803–10. doi:10.1242/jcs.03270. PMID 17130294. 
  8. ^ Lake AC, Bialik A, Walsh K, Castellot JJ (Jan 2003). "CCN5 is a growth arrest-specific gene that regulates smooth muscle cell proliferation and motility". The American Journal of Pathology. 162 (1): 219–31. doi:10.1016/S0002-9440(10)63813-8. PMC 1851113Freely accessible. PMID 12507905. 
  9. ^ Mason HR, Lake AC, Wubben JE, Nowak RA, Castellot JJ (Mar 2004). "The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells". Molecular Human Reproduction. 10 (3): 181–7. doi:10.1093/molehr/gah028. PMID 14981145. 
  10. ^ Fritah A, Saucier C, De Wever O, Bracke M, Bièche I, Lidereau R, Gespach C, Drouot S, Redeuilh G, Sabbah M (Feb 2008). "Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells". Molecular and Cellular Biology. 28 (3): 1114–23. doi:10.1128/MCB.01335-07. PMC 2223394Freely accessible. PMID 18070926. 
  11. ^ Banerjee S, Dhar G, Haque I, Kambhampati S, Mehta S, Sengupta K, Tawfik O, Phillips TA, Banerjee SK (Sep 2008). "CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells". Cancer Research. 68 (18): 7606–12. doi:10.1158/0008-5472.CAN-08-1461. PMID 18794149. 
  12. ^ Yoon PO, Lee MA, Cha H, Jeong MH, Kim J, Jang SP, Choi BY, Jeong D, Yang DK, Hajjar RJ, Park WJ (Aug 2010). "The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis". Journal of Molecular and Cellular Cardiology. 49 (2): 294–303. doi:10.1016/j.yjmcc.2010.04.010. PMID 20430035.