It lies on the right bank of the Meuse River, from the valley of the Chiers in the north to the town of Neufchâteau in the south. To the west, the region follows the Meuse, and to the east, it extends into the neighbouring department of Meurthe-et-Moselle. The Lac de Madine lies in the Woëvre, like does the western part of the Parc naturel régional de Lorraine. Neighbouring natural regions include the Côtes de Meuse on the left bank of the Meuse, the Barrois to the south and the Côtes de Moselle to the east. The Belgian Ardennes lie to the north.
Certain areas are designated as "Zones naturelles d'intérêt écologique, faunistique et floristique", or ZNIEFFs, which marks them as particularly important to the preservation of France's ecological heritage either because of the plants or animals they support, their ecological role or their local or national importance. The "Conservatoire des sites lorraines" was created to protect endangered species, and it purchased most of the areas in 1994.
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