XPNPEP2

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XPNPEP2
Identifiers
Aliases XPNPEP2, AEACEI, APP2, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
External IDs MGI: 2180001 HomoloGene: 37766 GeneCards: XPNPEP2
RNA expression pattern
PBB GE XPNPEP2 216910 at fs.png

PBB GE XPNPEP2 206484 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003399

NM_001289729
NM_133213

RefSeq (protein)

NP_003390

NP_001276658
NP_573476

Location (UCSC) Chr X: 129.74 – 129.77 Mb Chr X: 48.11 – 48.14 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Xaa-Pro aminopeptidase 2 is an enzyme that in humans is encoded by the XPNPEP2 gene.[3][4][5]

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Venema RC, Ju H, Zou R, Venema VJ, Ryan JW (Dec 1997). "Cloning and tissue distribution of human membrane-bound aminopeptidase P". Biochim Biophys Acta. 1354 (1): 45–8. doi:10.1016/s0167-4781(97)00126-7. PMID 9375790. 
  4. ^ Sprinkle TJ, Stone AA, Venema RC, Denslow ND, Caldwell C, Ryan JW (Apr 1999). "Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25". Genomics. 50 (1): 114–6. doi:10.1006/geno.1998.5302. PMID 9628831. 
  5. ^ a b "Entrez Gene: XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound". 

Further reading[edit]