YAF2

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YAF2
Protein YAF2 PDB 2d9g.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases YAF2
External IDs HomoloGene: 136401 GeneCards: YAF2
RNA expression pattern
PBB GE YAF2 206238 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001177906
NP_001177908
NP_001177909
NP_001307009
NP_005739

n/a

Location (UCSC) Chr 12: 42.16 – 42.24 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.[2][3]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.[3]

References[edit]

Further reading[edit]

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