YoungSoo Kim
YoungSoo Kim | |
|---|---|
| 김영수 | |
| Born | April 7, 1978 |
| Scientific career | |
| Fields | Chemical Biology |
| Doctoral advisor | Kim D. Janda |
| Website | http://chembio.yonsei.ac.kr |
YoungSoo Kim (born April 7, 1978) is a South Korean chemist. At Yonsei University, Kim is an Assistant Professor in two departments; Integrated Science and Engineering Division (ISED), of Underwood International College (UIC), and Department of Pharmacy.
Education
Kim completed his B.A. degree in Biochemistry from New York University in 2001, with Professor Young-Tae Chang as an undergraduate research advisor. He then studied Bioorganic Chemistry under the supervision of Professor Kim D. Janda at The Scripps Research Institute and obtained his Ph.D. degree[1] in Chemistry in 2006.
Academic career
In 2006, Kim joined Korea Institute of Science and Technology (KIST) as a Research Scientist. In 2010, after his military service duty, he became a Principal Investigator of Brain Science Institute at KIST and Associate Professor of Biological Chemistry at Korea University of Science and Technology (UST). In 2017, he moved to Yonsei University as an Assistant Professor of Bio-Convergence (ISED) and Pharmacy. His laboratory is located at Yonsei University International Campus[2][3] in Songdo International Business District. Kim is an Editorial Board Member of Scientific Reports since 2015.[4]
Research
Kim's work focuses on pathology, therapeutics, and diagnostics of Alzheimer disease by using Chemical Biology as a research tool. A significant effort of the Kim laboratory in recent years has been to identify small molecules that control protein misfolding and cognitive impairments of Alzheimer's disease. Such research achievements in taurine derivatives reversing Alzheimer pathology[5][6] and Alzheimer blood tests detecting plasma amyloid-beta[7][8][9][10] contributed to rank Korea Institute of Science and Technology #6 among The World’s Most Innovative Research Institutions, selected by Reuters, in 2016[11] and 2017.[12] Examples of such molecules discovered include:
- EPPS, a small molecule disaggregating amyloid-beta oligomers and plaques[5][13][14][15]
- Taurine, a food supplement recovering learning and memory[6]
- Necrostatin-1, an anti-necroptotic molecule regulating both amyloid-beta misfolding and tau hyperphosphorylation[16]
External links
References
- ^ "TSRI Kellogg School's Entering Class in 2002".
{{cite news}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Underwood International College - Faculty Page". Yonsei University. Retrieved 2017-05-13.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "College of Pharmacy". Yonsei University. Retrieved 2017-05-13.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Editorial Advisory Panel and Editorial Board". Scientific Reports.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ a b "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 2015.
- ^ a b "Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease". Scientific Reports. 2014.
- ^ "Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model". Scientific Reports. 2014.
- ^ "Age-dependent inverse correlations in CSF and plasma amyloid-β(1–42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice". Scientific Reports. 2015.
- ^ "Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model". Scientific Reports. 2015.
- ^ "Early Dementia Diagnosis Based on Blood Test to Become Possible in 2019". Business Korea. 2016.
{{cite news}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Top 25 Global Innovators - #6 Korea Institute of Science & Technology in 2016". Reuters.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Top 25 Global Innovators - #6 Korea Institute of Science & Technology in 2017". Reuters.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Molecule clears Alzheimer's plaques in mice". BBC. 2015.
{{cite news}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Taurine-like chemical restores cognitive function in mice with Alzheimer's". The Guardian. 2015.
{{cite news}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil". Scientific Reports. 2016.
- ^ "Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mic". EMBO Molecular Medicine. 2017.
