ZKSCAN5

ZKSCAN5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EM5, 2EMM, 2EMZ, 2EN3, 2EOM, 2EON, 2EOO, 2YSO, 2YTG
Identifiers
Aliases	ZKSCAN5, ZFP95, ZNF914, ZSCAN37, ZFP-95, zinc finger with KRAB and SCAN domains 5
External IDs	OMIM: 611272; MGI: 107533; HomoloGene: 8734; GeneCards: ZKSCAN5; OMA:ZKSCAN5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	99,534,700 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	145,158,560 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; gonad; ; testicle; ; ventricular zone; ; ganglionic eminence; ; sperm; ; stromal cell of endometrium; ; muscle of thigh; ; islet of Langerhans; ; gastrocnemius muscle;
	Top expressed in
	secondary oocyte; ; spermatocyte; ; zygote; ; primary oocyte; ; ankle joint; ; seminiferous tubule; ; ventricular zone; ; genital tubercle; ; muscle of thigh; ; female urethra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus;
Biological process	transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	23660
	22757
	ENSG00000196652
	ENSMUSG00000055991
	Q9Y2L8
	Q9Z1D8
	NM_014569; NM_145102; NM_001318082; NM_001318083; NM_001318084
NM_001167944; NM_016683; NM_001359187; NM_001359188; NM_001359189;
	NM_001359190; NM_001359191; NM_001359192
	NP_001305011; NP_001305012; NP_001305013; NP_055384; NP_659570
NP_001161416; NP_057892; NP_001346116; NP_001346117; NP_001346118;
	NP_001346119; NP_001346120; NP_001346121
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein with KRAB and SCAN domains 5 is a protein that in humans is encoded by the ZKSCAN5 gene.^[5]^[6] The protein contains a SCAN box and a KRAB A domain.

A similar protein in mice is differentially expressed in spermatogenesis. Two alternatively spliced transcript variants differing only in the five prime untranslated region (5' UTR) have been described. Additional variants have been found, but their full-length sequences have not been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196652 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055991 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dreyer SD, Zheng Q, Zabel B, Winterpacht A, Lee B (Feb 2000). "Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain". Genomics. 62 (1): 119–22. doi:10.1006/geno.1999.5981. PMID 10585779.
^ ^a ^b "Entrez Gene: ZKSCAN5 zinc finger with KRAB and SCAN domains 5".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Thompson EE, Kuttab-Boulos H, Yang L, et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347. PMID 16314882.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196652 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055991 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585779-5] Dreyer SD, Zheng Q, Zabel B, Winterpacht A, Lee B (Feb 2000). "Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain". Genomics. 62 (1): 119–22. doi:10.1006/geno.1999.5981. PMID 10585779.

[entrez-6] "Entrez Gene: ZKSCAN5 zinc finger with KRAB and SCAN domains 5".

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References

Further reading