ZRSR2

ZRSR2
Identifiers
Aliases	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZC3H22, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
External IDs	OMIM: 300028; MGI: 103287; HomoloGene: 21061; GeneCards: ZRSR2; OMA:ZRSR2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	15,830,694 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	162,741,657 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; granulocyte; ; monocyte; ; tendon of biceps brachii; ; external globus pallidus; ; tibial arteries; ; spleen; ; gastric mucosa; ; Descending thoracic aorta; ; lymph node;
	Top expressed in
	genital tubercle; ; tail of embryo; ; yolk sac; ; retinal pigment epithelium; ; zygote; ; primitive streak; ; embryo; ; Epithelium of choroid plexus; ; granulocyte; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; nucleic acid binding; pre-mRNA 3'-splice site binding; RNA binding; protein binding;
Cellular component	nucleus; spliceosomal complex; U12-type spliceosomal complex; nucleoplasm; U2AF complex;
Biological process	mRNA processing; spliceosomal complex assembly; RNA splicing; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	8233
	22184
	ENSG00000169249
	ENSMUSG00000031370
	Q15696
	Q62377
	NM_005089
	NM_009453; NM_178794
	NP_005080
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.^[5]^[6]^[7]^[8]

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169249 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031370 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe T, Mitsuya K, Oshimura M, Murata A, et al. (Mar 1996). "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1". Genomics. 30 (2): 257–63. doi:10.1006/geno.1995.9879. PMID 8586425.
^ Tronchere H, Wang J, Fu XD (Aug 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. Bibcode:1997Natur.388..397T. doi:10.1038/41137. PMID 9237760. S2CID 4386808.
^ Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Luhrmann R (May 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
^ ^a ^b "Entrez Gene: ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2".

Brunner B, Todt T, Lenzner S, et al. (1999). "Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1". Genome Res. 9 (5): 437–48. doi:10.1101/gr.9.5.437. PMC 310778. PMID 10330123.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169249 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031370 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586425-5] Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe T, Mitsuya K, Oshimura M, Murata A, et al. (Mar 1996). "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1". Genomics. 30 (2): 257–63. doi:10.1006/geno.1995.9879. PMID 8586425.

[pmid9237760-6] Tronchere H, Wang J, Fu XD (Aug 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. Bibcode:1997Natur.388..397T. doi:10.1038/41137. PMID 9237760. S2CID 4386808.

[pmid15146077-7] Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Luhrmann R (May 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.

[entrez-8] "Entrez Gene: ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2".

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References

Further reading