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Zinc finger protein 280b

From Wikipedia, the free encyclopedia
ZNF280B
Identifiers
AliasesZNF280B, 5'OY11.1, D87009.C22.3, SUHW2, ZNF279, ZNF632, zinc finger protein 280B
External IDsMGI: 1927865; HomoloGene: 62794; GeneCards: ZNF280B; OMA:ZNF280B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080764

NM_177475

RefSeq (protein)

NP_542942

NP_803426

Location (UCSC)Chr 22: 22.48 – 22.51 MbChr 10: 75.87 – 75.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.[5]

Function

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The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.

References

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  1. ^ a b c ENSG00000277421 GRCh38: Ensembl release 89: ENSG00000275004, ENSG00000277421Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049764Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger protein 280B".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.