Zinc finger protein basonuclin-2 is a protein that in humans is encoded by the BNC2gene.[5][6]
BCN2 has recently been shown to influence skin pigmentation levels in Europeans.[7] Genomic region spanning the BCN2 gene has 60% Neanderthal DNA sequence.[8]
^Jacobs LC, Wollstein A, Lao O, Hofman A, Klaver CC, Uitterlinden AG, Nijsten T, Kayser M, Liu F (Feb 2013). "Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans". Human Genetics. 132 (2): 147–58. doi:10.1007/s00439-012-1232-9. PMID23052946.
^Vattathil S, Akey JM (Oct 2015). "Small Amounts of Archaic Admixture Provide Big Insights into Human History". Cell. 163 (2): 281–4. doi:10.1016/j.cell.2015.09.042. PMID26451479.
Further reading
Vanhoutteghem A, Djian P (Jan 2007). "The human basonuclin 2 gene has the potential to generate nearly 90,000 mRNA isoforms encoding over 2000 different proteins". Genomics. 89 (1): 44–58. doi:10.1016/j.ygeno.2006.07.006. PMID16942855.
Benevolenskaya EV, Murray HL, Branton P, Young RA, Kaelin WG (Jun 2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Molecular Cell. 18 (6): 623–35. doi:10.1016/j.molcel.2005.05.012. PMID15949438.
Romano RA, Li H, Tummala R, Maul R, Sinha S (May 2004). "Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes". Genomics. 83 (5): 821–33. doi:10.1016/j.ygeno.2003.11.009. PMID15081112.