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Z-DNA binding protein 1, also known as Zuotin, is a Saccharomyces cerevisiae yeast gene.

Zuo1 has been identified in vitro as a tRNA and Z-DNA binding protein.[1][2] The name "zuotin" is derived from the Chinese word "zuo" meaning "left". It is a member of Hsp40 family. Like all other Hsp40 members it also contains a classic J domain. It associates with Ssz1p to form a ribosome associated complex (RAC).


  1. ^ Zhang S, Lockshin C, Herbert A, Winter E & Rich A (1992). "Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae". EMBO J. 11 (10): 3787–3796. PMC 556839. PMID 1396572.
  2. ^ Wilhelm ML, Reinholt J, Gangloff J, Dirheimer G & Wilhelm FX (1994). "Transfer RNA binding protein in the nucleus of Saccharomyces cerevisiae". FEBS Lett. 349 (2): 260–264. doi:10.1016/0014-5793(94)00683-0. PMID 8050578.